Brooks W M, Haseler L J, Clarke K, Willis R J
J Mol Cell Cardiol. 1986 Feb;18(2):149-55. doi: 10.1016/s0022-2828(86)80467-9.
The relation between the PC/ATP ratio and left ventricular function was examined in the Langendorff-perfused guinea-pig heart over a range of perfusion flow rates. PC/ATP ratios were determined from the 31P-nuclear magnetic resonance spectra of hearts obtained at 80.98 MHz and ventricular function estimated by measuring pressure in the left ventricle. When flow rates were increased over the range 0.6 to 6.0 ml/min, the PC/ATP ratio increased from 0.64 +/- 0.05 at 0.6 ml/min to 1.82 +/- 0.12 at 3.8 ml/min with no further increase up to a flow rate of 6.0 ml/min. Developed pressure (DP) increased with the flow rate up to 6.0 ml/min but the end diastolic pressure (EDP) also increased. The DP/EDP ratio was found to correlate closely with the PC/ATP ratio over the range of flow rates examined. The PC/ATP ratio may be a practical index of myocardial function available to the clinician when the topical magnetic resonance technique is fully developed.
在一系列灌注流速下，对Langendorff灌注的豚鼠心脏中PC/ATP比值与左心室功能之间的关系进行了研究。PC/ATP比值由在80.98 MHz下获得的心脏31P-核磁共振光谱测定，心室功能通过测量左心室内压力来估计。当流速在0.6至6.0 ml/min范围内增加时，PC/ATP比值从0.6 ml/min时的0.64±0.05增加至3.8 ml/min时的1.82±0.12，直至流速达到6.0 ml/min时不再进一步增加。舒张期压力（DP）随流速增加直至6.0 ml/min，但舒张末期压力（EDP）也增加。在所研究的流速范围内，发现DP/EDP比值与PC/ATP比值密切相关。当局部磁共振技术充分发展时，PC/ATP比值可能成为临床医生可用的心肌功能实用指标。
