Cikrt M, Basinger M A, Jones S G, Jones M M
J Toxicol Environ Health. 1986;17(4):429-39. doi: 10.1080/15287398609530837.
The dithiocarbamate enhancement of the biliary excretion of cadmium in rats loaded with cadmium (by either the oral or sc route) was found to be strongly dependent on the structure of the groups attached to the nitrogen atom of the dithiocarbamate moiety. Those dithiocarbamates containing hydroxyl-bearing attached groups were found to be capable of causing the greatest enhancement of the cadmium content of the bile. For the compounds of this type that were examined, this enhancement of biliary cadmium content varied from 30-fold to over 2000-fold. No enhancement of the biliary excretion of cadmium was found subsequent to the administration of sodium diethyldithiocarbamate, though this compound is known to cause a significant increase in the fecal excretion of cadmium.
研究发现，二硫代氨基甲酸盐对经口或皮下途径染镉大鼠胆汁中镉排泄的促进作用，强烈依赖于连接在二硫代氨基甲酸盐部分氮原子上的基团结构。那些含有带羟基连接基团的二硫代氨基甲酸盐，被发现能够使胆汁中的镉含量得到最大程度的提高。对于所检测的这类化合物，胆汁中镉含量的提高幅度在30倍至2000倍以上。尽管已知二乙基二硫代氨基甲酸钠会使镉的粪便排泄量显著增加，但在给予该化合物后，未发现胆汁中镉排泄有增加。
