Kojima S, Kiyozumi M, Honda T, Kaminaka K, Oda Y, Senba Y
Toxicology. 1987 Jul;45(1):93-102. doi: 10.1016/0300-483x(87)90117-x.
The effect of sodium N-benzyl-D-glucamine dithiocarbamate (NBG-DTC) on the distribution and excretion of cadmium in rats exposed to cadmium and the chemical form and intestinal reabsorption of cadmium compound excreted in the bile were studied. Rats were injected intraperitoneally with 109CdCl2 (1 mg Cd and 10 microCi 109Cd/kg) and 24 h later, they were injected with NBG-DTC (400 or 1200 mumol/kg). The biliary excretion of cadmium was remarkably increased by intraperitoneally injection of NBG-DTC, while there was only a small increase in urinary excretion of cadmium. Such an enhancement effect of NBG-DTC on the biliary excretion of cadmium was much larger at the high dose (1200 mumol/kg) of NBG-DTC. The treatment with NBG-DTC significantly decreased the cadmium content in the liver at the dose of 1200 mumol/kg and did not result in the undesirable redistribution of cadmium to the tissues, such as brain, testes, heart and lung. In addition, it was found that the cadmium compound excreted in the bile was mainly characterized as cadmium-NBG-DTC and which was not reabsorbed from the intestinal tracts.
研究了N-苄基-D-葡糖胺二硫代甲酸钠（NBG-DTC）对镉暴露大鼠体内镉分布和排泄的影响，以及胆汁中排泄的镉化合物的化学形态和肠道重吸收情况。大鼠腹腔注射109CdCl2（1毫克镉和10微居里109Cd/千克），24小时后，注射NBG-DTC（400或1200微摩尔/千克）。腹腔注射NBG-DTC可显著增加镉的胆汁排泄，而镉的尿液排泄仅有少量增加。NBG-DTC对镉胆汁排泄的这种增强作用在高剂量（1200微摩尔/千克）的NBG-DTC时更大。在1200微摩尔/千克的剂量下，NBG-DTC处理显著降低了肝脏中的镉含量，并且没有导致镉向脑、睾丸、心脏和肺等组织的不良重新分布。此外，发现胆汁中排泄的镉化合物主要为镉-NBG-DTC，且不会从肠道重吸收。
