Enteric Pathogens in Humans, Domesticated Animals, and Drinking Water in a Low-Income Urban Area of Nairobi, Kenya.

To explore the sources of and associated risks with drinking water contamination in low-income, densely populated urban areas, we collected human feces, domesticated animal feces, and source and stored drinking water samples in Nairobi, Kenya in 2019; and analyzed them using microbial source tracking (MST) and enteric pathogen TaqMan Array Cards (TACs). We established host-pathogen relationships in this setting, including detecting and Norovirus─which are typically associated with humans─in dog feces. We evaluated stored and source drinking water quality using indicator (), MST markers, and TACs, detecting pathogen targets in drinking water that were also detected in specific animal feces. This work highlights the need for further evaluation of host-pathogen relationships and the directionality of pathogen transmission to prevent the disease burden associated with unsafe drinking water and domestic animal ownership.