1例由新型隐球菌序列型引起的隐球菌病，患者为人类免疫缺陷病毒感染者。
A Case of Cryptococcosis Due to a New Cryptococcus Neoformans Sequence Type in a Patient with Human Immunodeficiency Virus Infection.
作者信息
Dai Fangfang, Yu Yanhua, Lou Jinli, Lu Xinxin
机构信息
Department of Clinical Laboratory, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Beijing Tongren Hospital, Capital Medical University, Beijing, China.
出版信息
Am J Trop Med Hyg. 2024 Nov 26;112(2):373-376. doi: 10.4269/ajtmh.23-0818. Print 2025 Feb 5.
In this article, we report a male patient infected with HIV presenting with cryptococcal meningitis, pneumonia, and bloodstream infection, along with intestinal obstruction and gastrointestinal bleeding. Cerebrospinal fluid and bloodstream analyses revealed the presence of Cryptococcus neoformans complex. The isolated strain was sequenced and was found to belong to Cryptococcus neoformans var. grubii with a new sequence type (ST). The strain led to fatal multisystemic cryptococcosis in a short time, and the patient died due to hemorrhagic shock because of gastrointestinal bleeding despite emergency rescue efforts. There are few reports about cryptococcosis in HIV-infected patients caused by new ST isolates. We report a new Cryptococcus neoformans ST (ST702) isolate causing infection in an HIV-infected patient, which merits further study and clinical attention.
在本文中，我们报告了一名感染HIV的男性患者，其表现为隐球菌性脑膜炎、肺炎、血流感染，同时伴有肠梗阻和胃肠道出血。脑脊液和血液分析显示存在新型隐球菌复合体。对分离出的菌株进行测序后发现，它属于新型隐球菌格鲁比变种，具有一种新的序列类型（ST）。该菌株在短时间内导致了致命的多系统隐球菌病，尽管进行了紧急抢救，患者仍因胃肠道出血导致失血性休克而死亡。关于由新的ST分离株引起的HIV感染患者隐球菌病的报道很少。我们报告了一种新的新型隐球菌ST（ST702）分离株在一名HIV感染患者中引起感染，这值得进一步研究和临床关注。
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