载脂蛋白B/载脂蛋白A1比值是胰腺癌的一个独立预后因素。
Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer.
作者信息
Li Chenxi, Yang Xuhui, Zhong Yan, Wang Wenying, Jin Xin, Bian Lihua, Wang Xiaona
机构信息
Senior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, PR China.
Department of Radiology, the Fourth Medical Center, Chinese PLA General Hospital, Beijing, PR China.
出版信息
Transl Oncol. 2025 Jan;51:102208. doi: 10.1016/j.tranon.2024.102208. Epub 2024 Nov 26.
OBJECTIVE
The relationship between serum lipids and prognosis of pancreatic cancer has not been confirmed. Our purpose in the study was to investigate the associations between serum lipids level and prognosis in patients with pancreatic cancer.
METHODS
A retrospective study was performed on 286 pancreatic cancer patients who admitted to our hospital from January 1, 2017 to December 31, 2021. Serum lipids level were recorded. Clinical-pathological characteristics, oncologic outcomes, progression free survival (PFS) and overall survival (OS) were collected. The prognostic significance was determined by Kaplan-Meier analysis and Cox proportional hazards regression model.
RESULTS
Regarding serum lipids level, compared to normal apolipoprotein B/ apolipoprotein A (ApoB/ApoA1), high ApoB/ApoA1 level indicated a shorter OS (HR:2.028, 95% CI: 1.174-2.504, P = 0.011) and a shorter PFS (HR:1.800, 95% CI: 1.076-3.009, P = 0.025). Other serum lipid molecules were not associated with PFS and OS.
CONCLUSION
ApoB/ApoA1 might be an independent prognostic factor of pancreatic cancer.
目的
血清脂质与胰腺癌预后之间的关系尚未得到证实。本研究的目的是探讨胰腺癌患者血清脂质水平与预后之间的关联。
方法
对2017年1月1日至2021年12月31日期间我院收治的286例胰腺癌患者进行回顾性研究。记录血清脂质水平。收集临床病理特征、肿瘤学结局、无进展生存期（PFS）和总生存期（OS）。通过Kaplan-Meier分析和Cox比例风险回归模型确定预后意义。
结果
关于血清脂质水平，与正常载脂蛋白B/载脂蛋白A（ApoB/ApoA1）相比，高ApoB/ApoA1水平表明OS较短（HR：2.028，95%CI：1.174-2.504，P = 0.011）和PFS较短（HR：1.800，95%CI：1.076-3.009，P = 0.025）。其他血清脂质分子与PFS和OS无关。
结论
ApoB/ApoA1可能是胰腺癌的独立预后因素。
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