• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

载脂蛋白B/载脂蛋白A1比值是胰腺癌的一个独立预后因素。

Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer.

作者信息

Li Chenxi, Yang Xuhui, Zhong Yan, Wang Wenying, Jin Xin, Bian Lihua, Wang Xiaona

机构信息

Senior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, PR China.

Department of Radiology, the Fourth Medical Center, Chinese PLA General Hospital, Beijing, PR China.

出版信息

Transl Oncol. 2025 Jan;51:102208. doi: 10.1016/j.tranon.2024.102208. Epub 2024 Nov 26.

DOI:10.1016/j.tranon.2024.102208
PMID:39591897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11629317/
Abstract

OBJECTIVE

The relationship between serum lipids and prognosis of pancreatic cancer has not been confirmed. Our purpose in the study was to investigate the associations between serum lipids level and prognosis in patients with pancreatic cancer.

METHODS

A retrospective study was performed on 286 pancreatic cancer patients who admitted to our hospital from January 1, 2017 to December 31, 2021. Serum lipids level were recorded. Clinical-pathological characteristics, oncologic outcomes, progression free survival (PFS) and overall survival (OS) were collected. The prognostic significance was determined by Kaplan-Meier analysis and Cox proportional hazards regression model.

RESULTS

Regarding serum lipids level, compared to normal apolipoprotein B/ apolipoprotein A (ApoB/ApoA1), high ApoB/ApoA1 level indicated a shorter OS (HR:2.028, 95% CI: 1.174-2.504, P = 0.011) and a shorter PFS (HR:1.800, 95% CI: 1.076-3.009, P = 0.025). Other serum lipid molecules were not associated with PFS and OS.

CONCLUSION

ApoB/ApoA1 might be an independent prognostic factor of pancreatic cancer.

摘要

目的

血清脂质与胰腺癌预后之间的关系尚未得到证实。本研究的目的是探讨胰腺癌患者血清脂质水平与预后之间的关联。

方法

对2017年1月1日至2021年12月31日期间我院收治的286例胰腺癌患者进行回顾性研究。记录血清脂质水平。收集临床病理特征、肿瘤学结局、无进展生存期（PFS）和总生存期（OS）。通过Kaplan-Meier分析和Cox比例风险回归模型确定预后意义。

结果

关于血清脂质水平，与正常载脂蛋白B/载脂蛋白A（ApoB/ApoA1）相比，高ApoB/ApoA1水平表明OS较短（HR：2.028，95%CI：1.174-2.504，P = 0.011）和PFS较短（HR：1.800，95%CI：1.076-3.009，P = 0.025）。其他血清脂质分子与PFS和OS无关。

结论

ApoB/ApoA1可能是胰腺癌的独立预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/283d/11629317/f124c70fc110/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/283d/11629317/f124c70fc110/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/283d/11629317/f124c70fc110/gr1.jpg

相似文献

1
Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer.载脂蛋白B/载脂蛋白A1比值是胰腺癌的一个独立预后因素。
Transl Oncol. 2025 Jan;51:102208. doi: 10.1016/j.tranon.2024.102208. Epub 2024 Nov 26.
2
Preoperative apolipoprotein B/apolipoprotein A1 ratio: a novel prognostic factor for gastric cancer.术前载脂蛋白B/载脂蛋白A1比值：胃癌的一种新的预后因素。
Onco Targets Ther. 2018 Apr 13;11:2169-2176. doi: 10.2147/OTT.S156690. eCollection 2018.
3
Low serum apolipoprotein A1 level predicts poor prognosis of patients with diffuse large B-cell lymphoma in the real world: a retrospective study.血清载脂蛋白 A1 水平低预示弥漫性大 B 细胞淋巴瘤患者的预后不良：一项回顾性研究。
BMC Cancer. 2024 Jan 12;24(1):62. doi: 10.1186/s12885-024-11818-5.
4
Preoperative apolipoprotein B/A1 ratio is an independent prognostic factor in metastatic renal cell carcinoma.术前载脂蛋白 B/A1 比值是转移性肾细胞癌的独立预后因素。
Urol Oncol. 2019 Mar;37(3):184.e9-184.e17. doi: 10.1016/j.urolonc.2018.11.010. Epub 2018 Nov 30.
5
Predictive value of preoperative platelet-to-albumin ratio and apolipoprotein B-to-apolipoprotein A1 ratio for osteosarcoma in children and adolescents: a retrospective study of 118 cases.术前血小板/白蛋白比值和载脂蛋白 B/载脂蛋白 A1 比值对儿童和青少年骨肉瘤的预测价值：118 例回顾性研究。
BMC Cancer. 2022 Jan 27;22(1):113. doi: 10.1186/s12885-022-09223-x.
6
[Correlation between Pretreatment Serum Apolipoprotein Level and Prognosis of Small Cell Lung Cancer Patients].[小细胞肺癌患者治疗前血清载脂蛋白水平与预后的相关性]
Zhongguo Fei Ai Za Zhi. 2020 Oct 20;23(10):845-851. doi: 10.3779/j.issn.1009-3419.2020.104.21.
7
Postoperative high-density lipoprotein cholesterol level: an independent prognostic factor for gastric cancer.术后高密度脂蛋白胆固醇水平：胃癌的独立预后因素
Front Oncol. 2022 Jul 18;12:884371. doi: 10.3389/fonc.2022.884371. eCollection 2022.
8
Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer.血清载脂蛋白 A1 水平降低与结直肠癌患者的不良生存和全身炎症反应有关。
Sci Rep. 2017 Jul 14;7(1):5374. doi: 10.1038/s41598-017-05415-9.
9
Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients.基于脂质指标比率的新参数提高了可切除结直肠癌患者血浆脂质水平的预后价值。
World J Gastrointest Surg. 2021 Jul 27;13(7):689-701. doi: 10.4240/wjgs.v13.i7.689.
10
Combined use of apolipoprotein B/apolipoprotein A1 ratio and non-high-density lipoprotein cholesterol before routine clinical lipid measurement in predicting coronary heart disease.在常规临床血脂检测前联合使用载脂蛋白B/载脂蛋白A1比值和非高密度脂蛋白胆固醇预测冠心病
Coron Artery Dis. 2014 Aug;25(5):433-8. doi: 10.1097/MCA.0000000000000100.

本文引用的文献

1
Proteogenomic Analysis Identifies a Causal Association between Plasma Apolipoprotein B Levels and Liver Cancer Risk.蛋白质基因组学分析鉴定出血浆载脂蛋白 B 水平与肝癌风险之间的因果关联。
J Proteome Res. 2024 Sep 6;23(9):4055-4066. doi: 10.1021/acs.jproteome.4c00397. Epub 2024 Aug 2.
2
SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation.SKP2 通过抑制 TRIM21 介导的 PSPC1 降解促进胰腺导管腺癌的转移。
Cancer Lett. 2024 Apr 10;587:216733. doi: 10.1016/j.canlet.2024.216733. Epub 2024 Feb 14.
3
Causal relationships between coffee intake, apolipoprotein B and gastric, colorectal, and esophageal cancers: univariable and multivariable Mendelian randomization.
咖啡摄入、载脂蛋白 B 与胃癌、结直肠癌和食管癌之间的因果关系：单变量和多变量孟德尔随机化。
Eur J Nutr. 2024 Mar;63(2):469-483. doi: 10.1007/s00394-023-03281-y. Epub 2023 Dec 1.
4
Acquired and intrinsic gemcitabine resistance in pancreatic cancer therapy: Environmental factors, molecular profile and drug/nanotherapeutic approaches.胰腺癌治疗中获得性和内在吉西他滨耐药性：环境因素、分子谱及药物/纳米治疗方法。
Environ Res. 2024 Jan 1;240(Pt 2):117443. doi: 10.1016/j.envres.2023.117443. Epub 2023 Oct 18.
5
Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer.术后 C 反应蛋白与白蛋白比值是胃癌的独立预后因素。
Eur J Med Res. 2023 Sep 21;28(1):360. doi: 10.1186/s40001-023-01334-w.
6
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer.细胞膜伪装的蟾毒灵靶向 NOD2 并克服胰腺癌的多药耐药性。
Drug Resist Updat. 2023 Nov;71:101005. doi: 10.1016/j.drup.2023.101005. Epub 2023 Aug 21.
7
Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance.胰腺癌转移、细胞可塑性和 EMT 的分子特征：临床前侵袭性和耐药性的联系。
Cancer Metastasis Rev. 2024 Mar;43(1):29-53. doi: 10.1007/s10555-023-10125-y. Epub 2023 Jul 15.
8
Apolipoproteins: New players in cancers.载脂蛋白：癌症中的新角色。
Front Pharmacol. 2022 Nov 25;13:1051280. doi: 10.3389/fphar.2022.1051280. eCollection 2022.
9
Postoperative high-density lipoprotein cholesterol level: an independent prognostic factor for gastric cancer.术后高密度脂蛋白胆固醇水平：胃癌的独立预后因素
Front Oncol. 2022 Jul 18;12:884371. doi: 10.3389/fonc.2022.884371. eCollection 2022.
10
Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery.血清载脂蛋白 B 与载脂蛋白 A-I 比值是接受新辅助放化疗加手术治疗的局部晚期直肠癌患者肝转移的独立预测因子。
BMC Cancer. 2022 Jan 3;22(1):7. doi: 10.1186/s12885-021-09101-y.