术后高密度脂蛋白胆固醇水平：胃癌的独立预后因素
Postoperative high-density lipoprotein cholesterol level: an independent prognostic factor for gastric cancer.
作者信息
Li Chenxi, Fu Yan, Li Qiuwen, Yang Xuhui, Wang Wenying, Jin Xin, Bian Lihua, Zhao Hui, Li Donghui, Gao Jie, Du Nan, Peng Liang
机构信息
Senior Department of Oncology, The Fifth Medical Center of People's Liberation Army (PLA) General Hospital, Beijing, China.
Senior Department of Obstetrics and Gynecology, The Seventh Medical Center of People' s Liberation Army General Hospital, Beijing, China.
出版信息
Front Oncol. 2022 Jul 18;12:884371. doi: 10.3389/fonc.2022.884371. eCollection 2022.
OBJECTIVE
The relationship between serum lipids and prognosis of gastric cancer has not been confirmed. Our purpose in the study was to investigate the associations between preoperative and postoperative serum lipids level and prognosis in patients with gastric cancer.
METHODS
A retrospective study was performed on 431 patients who received radical (R0) gastrectomy from 2011 to 2013. Preoperative and postoperative serum lipids level were recorded. Clinical-pathological characteristics, oncologic outcomes, disease-free survival (DFS) and overall survival (OS) were collected. The prognostic significance was determined by Kaplan-Meier analysis and Cox proportional hazards regression model.
RESULTS
There was no significant difference in DFS and OS according to preoperative serum lipids level. Regarding postoperative serum lipids level, compared to normal high-density lipoprotein cholesterol (HDL-C), low postoperative HDL-C level indicated a shorter OS (hazard ratio: 1.76, 99% confidence interval: 1.31-2.38; P=0.000) and a shorter DFS (hazard ratio: 2.06, 99% confidence interval: 1.55-2.73; P=0.000). However, other postoperative serum lipid molecules were not associated with DFS and OS.
CONCLUSION
Postoperative HDL-C might be an independent prognostic factor of gastric cancer.
目的
血清脂质与胃癌预后之间的关系尚未得到证实。本研究的目的是探讨胃癌患者术前和术后血清脂质水平与预后之间的关联。
方法
对2011年至2013年接受根治性（R0）胃切除术的431例患者进行回顾性研究。记录术前和术后血清脂质水平。收集临床病理特征、肿瘤学结局、无病生存期（DFS）和总生存期（OS）。通过Kaplan-Meier分析和Cox比例风险回归模型确定预后意义。
结果
根据术前血清脂质水平，DFS和OS无显著差异。关于术后血清脂质水平，与正常高密度脂蛋白胆固醇（HDL-C）相比，术后HDL-C水平低表明OS较短（风险比：1.76，99%置信区间：1.31-2.38；P = 0.000）和DFS较短（风险比：2.06，99%置信区间：1.55-2.73；P = 0.000）。然而，其他术后血清脂质分子与DFS和OS无关。
结论
术后HDL-C可能是胃癌的独立预后因素。
Zotero 插件