Yamey Gavin, McDade Kaci Kennedy, Anderson Roy M, Bartsch Sarah M, Bottazzi Maria Elena, Diemert David, Hotez Peter J, Lee Bruce Y, McManus Donald, Molehin Adebayo J, Roestenberg Meta, Rollinson David, Siddiqui Afzal A, Tendler Miriam, Webster Joanne P, You Hong, Zellweger Raphaël M, Marshall Caroline
Duke Global Health Institute, Duke University, Durham, NC, United States.
Faculty of Medicine, School of Public Health, Imperial College London, London, United Kingdom.
Vaccine. 2024 Jul 23:126020. doi: 10.1016/j.vaccine.2024.05.068.
Schistosomiasis is caused by parasitic flatworms (Schistosoma). The disease in humans can be caused by seven different species of Schistosoma: S. mansoni, S. japonicum, S. haematobium, S. malayensis, S. mekongi, S. guineensis and S. intercalatum, as well as by hybrids between species, including livestock schistosome species. People are infected when exposed to infested water and the parasite larvae penetrate the skin. Poor and rural communities are typically the most affected, and the general population who lives in affected areas and is exposed to contaminated water is at risk. Areas with poor access to safe water and adequate sanitation are also at heightened risk. About 236.6 million people required treatment for schistosomiasis in 2019-mostly people living in poor, rural communities, especially fishing and agricultural communities. This 'Vaccine Value Profile' (VVP) for schistosomiasis is intended to provide a high-level, holistic assessment of the information and data that are currently available to inform the potential public health, economic, and societal value of pipeline vaccines and vaccine-like products. This VVP was developed by a working group of subject matter experts from academia, non-profit organizations, public private partnerships, and multi-lateral organizations. All contributors have extensive expertise on various elements of the schistosomiasis VVP and collectively aimed to identify current research and knowledge gaps. The VVP was developed using only existing and publicly available information.
血吸虫病由寄生扁虫（血吸虫属）引起。人类的这种疾病可由七种不同的血吸虫物种导致：曼氏血吸虫、日本血吸虫、埃及血吸虫、马来血吸虫、湄公血吸虫、几内亚血吸虫和间插血吸虫，以及物种间的杂交种，包括家畜血吸虫物种。当人们接触受感染的水且寄生虫幼虫穿透皮肤时就会被感染。贫困和农村社区通常受影响最大，生活在疫区且接触受污染水的普通人群也有感染风险。安全用水和卫生设施获取不便的地区风险也更高。2019年约有2.366亿人需要接受血吸虫病治疗，其中大多数是生活在贫困农村社区的人，尤其是渔业和农业社区的居民。这份血吸虫病“疫苗价值概况”（VVP）旨在对现有信息和数据进行高层次的全面评估，以为处于研发阶段的疫苗及类似疫苗产品的潜在公共卫生、经济和社会价值提供参考。这份VVP由来自学术界、非营利组织、公私合作伙伴关系及多边组织的主题专家工作小组编制。所有贡献者在血吸虫病VVP的各个方面都有广泛的专业知识，共同旨在找出当前的研究和知识差距。VVP仅使用现有公开信息编制而成。
