Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, 69 Pasteur Ave., Tehran, 1316943551, Iran.
Department of Epidemiology, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.
Virol J. 2024 Nov 26;21(1):305. doi: 10.1186/s12985-024-02574-w.
Dengue virus (DENV) and Chikungunya virus (CHIKV) are the most common arthropod-borne viruses (Arboviruses) globally. So far, no autochthonous cases of DENV and CHIKV infections have been reported in Iran. Nevertheless, due to the recent identification of Aedes aegypti in the south and Aedes albopictus in the north of Iran, the country is at a serious risk of local outbreaks of these infections.
Between 2020 and 2023, a comprehensive cross-sectional study was conducted to explore the anti-DENV and CHIKV IgG antibodies in the general populations of both southern and northern regions of Iran using ELISA.
A total of 11,192 participants were included, of whom 2.3% (256 individuals) and 0.1% (11 cases) were DENV seropositive and CHIK seropositive, respectively. Across the eight examined provinces, Sistan and Baluchestan province displayed the highest prevalence of dengue seropositive cases (6.80%) (P < 0.001). Samples collected in 2022 demonstrated a notably higher seropositive rate of 5.5% (P < 0.001). Interestingly, all 11 CHIKV seropositive cases were from Sistan and Baluchestan province.
The seroprevalence of DENV was notably higher in southern regions, particularly in Sistan and Baluchestan province and CHIKV seropositive cases were exclusively found in Sistan and Baluchestan province. This study furnishes crucial insights into the seroepidemiology of DENV and CHIKV in Iran, which in conjunction with the presence of Ae. aegypti in the south and Ae. albopictus in the north of Iran, emphasizes the requirement of improving integrated surveillance and control systems in the whole of the country, especially in the south of Iran.
登革热病毒（DENV）和基孔肯雅热病毒（CHIKV）是全球最常见的虫媒病毒（Arboviruses）。迄今为止，伊朗尚未报告本地感染 DENV 和 CHIKV 的病例。然而，由于最近在伊朗南部发现埃及伊蚊，北部发现白纹伊蚊，该国正面临这些感染本地爆发的严重风险。
2020 年至 2023 年，采用 ELISA 法对伊朗南部和北部的一般人群进行了一项全面的横断面研究，以探索抗 DENV 和 CHIKV IgG 抗体。
共纳入 11192 名参与者，其中 2.3%（256 人）和 0.1%（11 例）为 DENV 血清阳性和 CHIK 血清阳性。在所检查的八个省份中，锡斯坦和俾路支省的登革热血清阳性病例比例最高（6.80%）（P<0.001）。2022 年采集的样本显示出明显更高的血清阳性率（5.5%）（P<0.001）。有趣的是，所有 11 例 CHIKV 血清阳性病例均来自锡斯坦和俾路支省。
DENV 的血清流行率在南部地区明显较高，特别是在锡斯坦和俾路支省，而 CHIKV 血清阳性病例仅在锡斯坦和俾路支省发现。本研究为伊朗 DENV 和 CHIKV 的血清流行病学提供了重要信息，结合伊朗南部存在埃及伊蚊和北部存在白纹伊蚊的情况，强调需要在全国范围内，特别是在伊朗南部，改善综合监测和控制系统。
