Santos Letícia L M, de Aquino Erika Carvalho, Fernandes Suleimy Marinho, Ternes Yves Mauro F, Feres Valéria C de R
Molecular Biology Laboratory and Technologies Applied to Laboratory Diagnosis Faculty of Pharmacy Federal University of Goias Goiânia Brazil Molecular Biology Laboratory and Technologies Applied to Laboratory Diagnosis, Faculty of Pharmacy, Federal University of Goias, Goiânia, Brazil.
Public Health Department Institute of Tropical Pathology and Public Health Federal University of Goias Goiânia Brazil Public Health Department, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia, Brazil.
Rev Panam Salud Publica. 2023 Feb 10;47:e34. doi: 10.26633/RPSP.2023.34. eCollection 2023.
To characterize the distribution profile of dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean and to identify possible factors associated with the risk of dissemination and severity of these arboviruses.
The protocol of this review was registered on the PROSPERO platform. Searches were carried out in the following databases: Virtual Health Library, MEDLINE/PubMed, and Embase. The search terms were: Zika virus, Zika virus infection, dengue, dengue virus, chikungunya virus, chikungunya fever, epidemiology, observational study, Latin America, and Caribbean region. Studies that addressed the distribution of these arboviruses and the risk factors associated with dengue, Zika virus disease, and chikungunya, published between January 2000 and August 2020 in English, Portuguese, and Spanish, were included.
Of 95 studies included, 70 identified risk factors, clinical manifestations, and outcomes for arbovirus infections and 25 described complications and/or deaths. The highest frequency of confirmed cases was for dengue. Brazil reported most cases of the three arboviruses in the period analyzed. Environmental and socioeconomic factors facilitated the proliferation and adaptation of vectors, and host-related factors were reported to aggravate dengue. Most deaths were due to chikungunya, Zika virus disease caused most neurological alterations, and dengue resulted in greater morbidity leading to more frequent hospitalization.
The review provides a broad view of the three arboviruses and the intrinsic aspects of infections, and highlights the factors that influence the spread of these viruses in the populations studied.
描述拉丁美洲和加勒比地区登革热、基孔肯雅热和寨卡病毒感染的分布特征，并确定与这些虫媒病毒传播风险和严重程度相关的可能因素。
本综述方案已在PROSPERO平台注册。在以下数据库中进行检索：虚拟健康图书馆、MEDLINE/PubMed和Embase。检索词为：寨卡病毒、寨卡病毒感染、登革热、登革热病毒、基孔肯雅热病毒、基孔肯雅热、流行病学、观察性研究、拉丁美洲和加勒比地区。纳入2000年1月至2020年8月期间以英文、葡萄牙文和西班牙文发表的涉及这些虫媒病毒分布以及与登革热、寨卡病毒病和基孔肯雅热相关危险因素的研究。
在纳入的95项研究中，70项确定了虫媒病毒感染的危险因素、临床表现和结局，25项描述了并发症和/或死亡情况。确诊病例频率最高的是登革热。在分析期间，巴西报告了这三种虫媒病毒的大多数病例。环境和社会经济因素促进了病媒的繁殖和适应，据报道宿主相关因素会加重登革热病情。大多数死亡是由基孔肯雅热导致的，寨卡病毒病引起的神经改变最多，登革热导致更高的发病率，从而使住院更为频繁。
本综述提供了对这三种虫媒病毒及其感染内在方面的广泛见解，并强调了影响这些病毒在所研究人群中传播的因素。
