Nanchang University Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
J Ovarian Res. 2024 Nov 26;17(1):237. doi: 10.1186/s13048-024-01551-9.
Follicular fluid (FF) plays a vital role in the bidirectional communication between oocytes and granulosa cells (GCs), regulating and promoting oocyte growth and development. This fluid constitutes a complex microenvironment, rich in various molecules including hormones, growth factors, cytokines, lipids, proteins, and extracellular vesicles. Understanding the composition and metabolic profile of follicular fluid is important for investigating ovarian pathologies such as polycystic ovary syndrome (PCOS) and endometriosis. Additionally, analyzing follicular fluid can offer valuable insights into oocyte quality, aiding in optimal oocyte selection for in vitro fertilization (IVF). This review provides an overview of follicular fluid composition, classification of its components and discusses the influential components of oocyte development. It also highlights the role of follicular fluid in the pathogenesis and diagnosis of ovarian diseases, along with potential follicular fluid biomarkers for assessing oocyte quality. By understanding the intricate relationship between follicular fluid and oocyte development, we can advance fertility research and improve clinical outcomes for infertility patients.
卵泡液（FF）在卵母细胞和颗粒细胞（GCs）之间的双向通讯中起着至关重要的作用，调节和促进卵母细胞的生长和发育。这种液体构成了一个复杂的微环境，富含各种分子，包括激素、生长因子、细胞因子、脂质、蛋白质和细胞外囊泡。了解卵泡液的组成和代谢特征对于研究多囊卵巢综合征（PCOS）和子宫内膜异位症等卵巢疾病非常重要。此外，分析卵泡液可以为卵母细胞质量提供有价值的见解，有助于体外受精（IVF）中最佳卵母细胞的选择。本文综述了卵泡液的组成、成分的分类，并讨论了影响卵母细胞发育的因素。还强调了卵泡液在卵巢疾病发病机制和诊断中的作用，以及评估卵母细胞质量的潜在卵泡液生物标志物。通过了解卵泡液和卵母细胞发育之间的复杂关系，我们可以推进生育研究并改善不孕患者的临床结局。
