Taieb Ach, Feryel Amri
Faculty of Medicine of Sousse, University of Sousse, Sousse 4000, Tunisia.
Department of Endocrinology, University Hospital of Farhat Hached Sousse, Sousse 4031, Tunisia.
Diagnostics (Basel). 2024 Nov 16;14(22):2578. doi: 10.3390/diagnostics14222578.
Polycystic ovary syndrome is a presvalent endocrine disorder affecting women globally, characterized by hormonal imbalance, metabolic disturbances, and reproductive dysfunction. Diagnosis relies on clinical evaluation, medical history assessment, physical examination, and laboratory tests, with the Rotterdam criteria being widely used. The pathophysiology of PCOS involves genetic predisposition, environmental factors, and lifestyle influences, with hormonal dysregulation, particularly elevated androgens, insulin resistance, and chronic inflammation, playing a pivotal role. These mechanisms not only contribute to reproductive and metabolic disturbances but also to the various cutaneous manifestations, such as acne, hirsutism, and alopecia. This review aims to analyze the role of androgens in the dermatological manifestations in patients with polycystic ovary syndrome, providing insights into underlying mechanisms and guiding the development of effective therapeutic strategies. By synthesizing available evidence, this review aims to deepen understanding of related dermatological manifestations and improve outcomes for affected individuals.
多囊卵巢综合征是一种在全球范围内影响女性的常见内分泌疾病，其特征为激素失衡、代谢紊乱和生殖功能障碍。诊断依赖于临床评估、病史评估、体格检查和实验室检查，其中鹿特丹标准被广泛应用。多囊卵巢综合征的病理生理学涉及遗传易感性、环境因素和生活方式影响，激素失调，尤其是雄激素升高、胰岛素抵抗和慢性炎症起着关键作用。这些机制不仅导致生殖和代谢紊乱，还导致各种皮肤表现，如痤疮、多毛症和脱发。本综述旨在分析雄激素在多囊卵巢综合征患者皮肤表现中的作用，深入了解潜在机制并指导有效治疗策略的制定。通过综合现有证据，本综述旨在加深对相关皮肤表现的理解并改善受影响个体的治疗效果。
