Liu Daohang, Yang Sha, Yu Shuguang
College of Acupuncture and Massage, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Antioxidants (Basel). 2024 Oct 30;13(11):1329. doi: 10.3390/antiox13111329.
Ischemic stroke is a devastating condition that occurs due to the interruption of blood flow to the brain, resulting in a range of cellular and molecular changes. In recent years, there has been growing interest in the role of ferroptosis, a newly identified form of regulated cell death, in ischemic stroke. Ferroptosis is driven by the accumulation of lipid peroxides and is characterized by the loss of membrane integrity. Additionally, oxidative stress, which refers to an imbalance between prooxidants and antioxidants, is a hallmark of ischemic stroke and significantly contributes to the pathogenesis of the disease. In this review, we explore the interactions between ferroptosis and oxidative stress in ischemic stroke. We examine the underlying mechanisms through which oxidative stress induces ferroptosis and how ferroptosis, in turn, exacerbates oxidative stress. Furthermore, we discuss potential therapeutic strategies that target both ferroptosis and oxidative stress in the treatment of ischemic stroke. Overall, this review highlights the complex interplay between ferroptosis and oxidative stress in ischemic stroke and underscores the need for further research to identify novel therapeutic targets for this condition.
缺血性中风是一种严重的疾病，由于大脑血液供应中断而发生，导致一系列细胞和分子变化。近年来，一种新发现的程序性细胞死亡形式——铁死亡在缺血性中风中的作用越来越受到关注。铁死亡由脂质过氧化物的积累驱动，其特征是膜完整性丧失。此外，氧化应激是指促氧化剂和抗氧化剂之间的失衡，是缺血性中风的一个标志，并在很大程度上促成了该疾病的发病机制。在这篇综述中，我们探讨了缺血性中风中铁死亡与氧化应激之间的相互作用。我们研究了氧化应激诱导铁死亡的潜在机制，以及铁死亡如何反过来加剧氧化应激。此外，我们讨论了在缺血性中风治疗中针对铁死亡和氧化应激的潜在治疗策略。总体而言，这篇综述强调了缺血性中风中铁死亡与氧化应激之间的复杂相互作用，并强调需要进一步研究以确定针对这种疾病的新治疗靶点。
