IVIRMA Global Research Alliance, IVIRMA Roma, Via Federico Calabresi, 11, 00169 Rome, Italy.
IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Avenida Fernando Abril Martorell, 106-Torre A, Planta 1, 46026 Valencia, Spain.
Cells. 2024 Nov 6;13(22):1836. doi: 10.3390/cells13221836.
Obesity is a multifactorial disease present worldwide and correlated with hormonal alterations that may cause a decrease in reproductive outcomes and seminal quality. However, the specific mechanisms involved are unknown. This led us to examine the relationship between paternal body mass index (BMI) and clinical reproductive outcomes by evaluating the cumulative live birth rates (CLBRs) per number of embryo transfers (ETs), embryos replaced (EmbRs), and oocytes used (OUs) in consecutive treatments until achieving the first newborn. A retrospective study was performed, and Kaplan-Meier survival curves were created to observe CLBRs with regard to the paternal BMI, adjusted by relevant confounders through Cox regression models. The participants were couples undergoing intracytoplasmic sperm injection (ICSI) and ET in Spanish IVIRMA clinics using autologous gametes. The cohort was subdivided based on paternal BMI: normal (18.5-24.99 kg/m) (N), overweight (25-29.99 kg/m) (OV), or obese (≥30 kg/m) (OB) patients. A total of 4750 ICSI cycles were included, encompassing 49,485 mature oocytes, 23,963 blastocysts, and 3048 ETs. When calculating CLBRs based on the number of ETs carried out until live birth was achieved, no statistically significant differences were found ( = 0.72). After adjusting for maternal age and BMI, female infertility diagnosis, the use of preimplantation genetic testing, and the number of ETs, Cox regression showed that there were no statistically significant differences between the BMI groups (HR: 0.94 [95% CI: 0.7-1.2]; = 0.59). When calculating CLBRs considering EmbRs, there was a similarity between the BMI groups ( = 0.57). However, there were no statistically significant differences in the adjusted Cox regression (HR: 0.93 [95% CI: 0.7-1.2]; = 0.51). Finally, when calculating CLBRs considering OUs, the results were comparable among BMI subgroups ( = 0.75), and there were no statistically significant differences with adjusted Cox regression (HR: 0.95 [95% CI: 0.8-1.2]; = 0.66). In conclusion, paternal BMI was not associated with clinical reproductive outcomes when considering the ETs, EmbRs, or OUs needed to reach the first liveborn (LB).
肥胖是一种全球性的多因素疾病，与激素改变相关，可能导致生殖结局和精液质量下降。然而，具体的发病机制尚不清楚。这促使我们通过评估连续治疗中每个胚胎移植（ET）、胚胎移植数（EmbR）和卵母细胞数（OU）所需的累积活产率（CLBR）来研究父体体重指数（BMI）与临床生殖结局之间的关系，直到获得第一个新生儿。进行了一项回顾性研究，并通过 Cox 回归模型，使用 Kaplan-Meier 生存曲线来观察与父体 BMI 相关的 CLBR，通过调整相关混杂因素进行校正。研究对象为在西班牙 IVIRMA 诊所接受胞浆内单精子注射（ICSI）和 ET 的夫妇，使用自体配子。该队列根据父体 BMI 进行了细分：正常（18.5-24.99 kg/m）（N）、超重（25-29.99 kg/m）（OV）或肥胖（≥30 kg/m）（OB）患者。共纳入 4750 个 ICSI 周期，包含 49485 个成熟卵母细胞、23963 个囊胚和 3048 个 ET。当根据实现活产所需的 ET 数量计算 CLBR 时，未发现统计学差异（=0.72）。调整母体年龄和 BMI、女性不孕诊断、使用植入前遗传学检测和 ET 数量后，Cox 回归显示 BMI 组之间无统计学差异（HR：0.94[95%CI：0.7-1.2]；=0.59）。当考虑 EmbR 计算 CLBR 时，BMI 组之间相似（=0.57）。然而，调整后的 Cox 回归无统计学差异（HR：0.93[95%CI：0.7-1.2]；=0.51）。最后，当考虑 OU 计算 CLBR 时，BMI 亚组之间的结果相似（=0.75），且调整后的 Cox 回归无统计学差异（HR：0.95[95%CI：0.8-1.2]；=0.66）。总之，当考虑实现首次活产所需的 ET、EmbR 或 OU 时，父体 BMI 与临床生殖结局无关。
