Use of to Unravel the Tripartite Interaction of Kynurenine Pathway, UPR and Microbiome in Parkinson's Disease.

The model organism and its relationship with the gut microbiome are gaining traction, especially for the study of neurodegenerative diseases such as Parkinson's Disease (PD). Gut microbes are known to be able to alter kynurenine metabolites in the host, directly influencing innate immunity in . While the mitochondrial unfolded protein response (UPR) was first characterized in in 2007, its relevance in host-microbiome interactions has only become apparent in recent years. In this review, we provide novel insights into the current understanding of the microbiome-gut-brain axis with a focus on tripartite interactions between the UPR, kynurenine pathway, and microbiome in , and explore their relationships for PD remediations.