Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
Marilia Medical School, Marilia 17519-030, SP, Brazil.
Int J Mol Sci. 2024 Nov 10;25(22):12064. doi: 10.3390/ijms252212064.
The human scalp is a common site of skin cancer in humans, with nonmelanoma skin cancer being exceedingly common. In this review, two dermatologists with extensive experience in cutaneous oncology will discuss unique features of the epidemiology of cancer of the scalp. Clinical observations on these common skin cancers lead to insight into the pathogenesis and potential prevention and treatment of cutaneous scalp neoplasia. Our hypothesis is that the presence of hair protects against the development of skin cancer but not by serving as a physical shield but rather by providing continuous IL-17-biased immunosurveillance. The loss of hair allows for a release from immunosurveillance, resulting in the expansion of neoplastic cells towards skin cancer. Both hair follicles and metabolic changes in stroma allow for permissiveness for tumor promotion.
头皮是人皮肤癌的常见部位，非黑色素瘤皮肤癌极其常见。在这篇综述中，两位在皮肤肿瘤学方面拥有丰富经验的皮肤科医生将讨论头皮癌的流行病学的独特特征。对这些常见皮肤癌的临床观察使我们深入了解头皮皮肤肿瘤的发病机制以及潜在的预防和治疗方法。我们的假设是，头发的存在可以预防皮肤癌的发生，但不是通过充当物理屏障，而是通过提供持续的 IL-17 偏向性免疫监视。头发的丧失会导致免疫监视的释放，从而导致肿瘤细胞向皮肤癌的扩张。毛囊和基质的代谢变化都允许肿瘤促进。
