Njeim Ryan, Pannala Sai Shanmukha Sreeram, Zaidan Nadim, Habib Toni, Rajamanuri Medha, Moussa Elie, Deeb Liliane, El-Sayegh Suzanne
Department of Medicine, Northwell Staten Island University Hospital, Staten Island, NY 10305, USA.
School of Medicine, Southern Illinois University, Springfield, IL 62702, USA.
J Clin Med. 2024 Nov 16;13(22):6908. doi: 10.3390/jcm13226908.
: Patients with autoimmune diseases experience a higher burden of metabolic syndrome (MetS) and cardiovascular disease (CVD). There is a paucity of data regarding MetS in patients with inflammatory bowel disease (IBD) and its impact on CVD. In this retrospective study, we aimed to evaluate the prevalence of MetS components in IBD patients, as well as their association with acute coronary syndrome (ACS), heart failure and arrhythmias. : After pooling 5 years of data from the National Inpatient Sample (NIS) Database (2016-2020), we compared traditional cardiovascular risk factors between IBD and non-IBD patients. We then investigated the association between MetS (represented by a calculated metabolic score (CMS) ranging from 0 to 4, based on the presence or absence of hypertension, obesity, dyslipidemia and type II diabetes) and CVD, separately for Crohn's disease (CD) and ulcerative colitis (UC) patients. : The prevalence of the different MetS components was found to be lower in IBD patients compared to non-IBD patients. Comparing CD (n = 806,875) and UC (n = 575,925) identified a higher prevalence of MetS components in UC. Higher CMS was positively associated with ACS and arrhythmias in both CD and UC. This association was evident in heart failure, with the odds ratio increasing from 2.601 for CMS = 1 to 6.290 for CMS = 4 in UC patients and from 2.622 to 5.709 in CD patients. : Our study highlights the positive association between traditional components of MetS and CVD in IBD patients. Our findings suggest that chronic inflammation explains only partially the CVD burden in hospitalized IBD patients.
自身免疫性疾病患者经历代谢综合征（MetS）和心血管疾病（CVD）的负担更高。关于炎症性肠病（IBD）患者的MetS及其对CVD影响的数据较少。在这项回顾性研究中，我们旨在评估IBD患者中MetS各组分的患病率，以及它们与急性冠状动脉综合征（ACS）、心力衰竭和心律失常的关联。：汇总来自国家住院样本（NIS）数据库（2016 - 2020年）的5年数据后，我们比较了IBD患者和非IBD患者之间的传统心血管危险因素。然后，我们分别针对克罗恩病（CD）和溃疡性结肠炎（UC）患者，研究了MetS（以基于高血压、肥胖、血脂异常和2型糖尿病的存在与否计算的代谢评分（CMS）范围为0至4表示）与CVD之间的关联。：发现IBD患者中不同MetS组分的患病率低于非IBD患者。比较CD（n = 806,875）和UC（n = 575,925）发现UC中MetS组分的患病率更高。较高的CMS与CD和UC患者的ACS和心律失常均呈正相关。在心力衰竭中这种关联很明显，UC患者中CMS = 1时比值比为2.601，CMS = 4时为6.290，CD患者中则从2.622增加到5.709。：我们的研究强调了IBD患者中MetS的传统组分与CVD之间的正相关。我们的研究结果表明，慢性炎症仅部分解释了住院IBD患者的CVD负担。
