Therapeutic Potential of Novel Silver Carbonate Nanostructures in Wound Healing and Antibacterial Activity Against and .

: Metallic NPs have been explored for various therapeutic uses owing to utilitarian physicochemical characteristics such as antibacterial, anti-inflammatory, and healing properties. The objective of this study is to evaluate the therapeutic potential of novel silver carbonate nanostructures in promoting wound healing and their antibacterial activity against and . : In this work, we prepared AgCO nanoparticles through a two-step methodology that was expected to improve the material's biomedical performance and biocompatibility. The characterization and assessment of synthesized NPs biocompatibility were conducted using hemolysis assays on the blood of a healthy male human. Further, we performed molecular docking analysis to confirm interactions of silver NPs with biological molecules. : In detail, the synthesized NPs showed <5% hemolysis activity at various concentrations, confirming their therapeutic applicability. Additionally, the NPs had good metabolic activities; they raised the T3/T4 hormone content and acted effectively on Insulin-like Growth Factor 1 (IGF-1) in diabetic models. They also facilitated the rate of repair by having the diabetic wounds reach 100% re-epithelialization by day 13, unlike the control group, which reached the same level only by day 16. The synthesized AgCO NPs exhibited high antimicrobial potential against both and hence being a potential material that can be used for infection control in biomedical tissue engineering applications. : These findings concluded that novel synthesis methods lead to the formation of NPs with higher therapeutic prospects; however, studies of their metaphysical and endocrinological effects are necessary.