Zhang Huishan, Lin Xiaoping
Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang, China.
J Int Med Res. 2024 Nov;52(11):3000605241300096. doi: 10.1177/03000605241300096.
Over the past few years, the correlation between periodontal disease (PD) and polycystic ovary syndrome (PCOS) has attracted widespread attention owing to the increased incidence of these diseases. Several studies have suggested a possible link between the two. In this narrative review, we examined the epidemiology, common risk factors, and pathological mechanisms of PCOS and PD to investigate the potential association between these diseases. Evidence from the literature indicates that PCOS and PD can interact with each other. Common risk factors, such as microbial homeostasis imbalance owing to dysbiosis, along with multiple hormone and inflammatory mediators, as well as inflammatory responses owing to oxidative stress and oxidative responses owing to ferroptosis, are all associated with the pathogenesis of both diseases. Further studies are needed to clarify the specific mechanisms of interaction between PCOS and PD, which could clarify future directions in disease management and combined multidisciplinary treatment.
在过去几年中，由于牙周病（PD）和多囊卵巢综合征（PCOS）的发病率上升，它们之间的相关性已引起广泛关注。多项研究表明这两者之间可能存在联系。在这篇叙述性综述中，我们研究了PCOS和PD的流行病学、常见风险因素及病理机制，以探讨这些疾病之间的潜在关联。文献证据表明，PCOS和PD可能相互作用。常见风险因素，如因生态失调导致的微生物稳态失衡，以及多种激素和炎症介质，还有氧化应激引起的炎症反应和铁死亡引起的氧化反应，均与这两种疾病的发病机制相关。需要进一步研究来阐明PCOS和PD之间相互作用的具体机制，这可能为疾病管理和联合多学科治疗明确未来方向。
