Yan Chadakan, Phinyo Phichayut, Yogya Yuri, Chuamanochan Mati, Wanitphakdeedecha Rungsima
Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Biomedical Informatics and Clinical Epidemiology (BioCE), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
J Cosmet Dermatol. 2025 Jan;24(1):e16695. doi: 10.1111/jocd.16695. Epub 2024 Nov 27.
One of the worst long-term effects of acne is scarring, which leads to significant physical, psychological, and economic burdens. Limited studies have specifically studied the risk factors for acne scarring. This study aims to explore risk factors associated with facial acne scarring in Thai patients with acne.
Exploratory cross-sectional risk factor research was conducted using an online questionnaire on Thai patients aged ≥ 18 years who were diagnosed with acne between September and December 2023. The primary objective was to identify significant determinants of acne scars in patients with acne, including sociodemographic factors, clinical factors of acne, lifestyle factors, dietary habits factors, and treatment factors. Univariable and multivariable logistic regression were used to identify significant risk determinants.
Of 225 patients with 61.33% prevalence of acne scarring, acne scarring was found to be independently associated with the following variables: moderate acne (mOR 3.51, 95% CI 1.31-9.40, p = 0.012) or severe-to-very severe acne (mOR 8.98, 95% CI 2.71-29.73, p < 0.001), sometimes squeezing and picking behaviors (mOR 2.69, 95% CI 2.71-29.73, p = 0.033), and postacne erythema (PAE) (mOR 4.46, 95% CI 1.96-10.14, p < 0.001).
The risk factors associated with acne scarring in individuals include the severity of acne, squeezing and picking behaviors, and experiencing PAE. One of this study's essential findings confirms that PAE is a notable component that could contribute to the development of acne scars. Early treatment of individuals at risk is crucial to reduce scar formation.
痤疮最严重的长期影响之一是瘢痕形成，这会导致巨大的身体、心理和经济负担。专门研究痤疮瘢痕危险因素的研究有限。本研究旨在探讨泰国痤疮患者面部痤疮瘢痕的相关危险因素。
采用在线问卷对2023年9月至12月期间诊断为痤疮的≥18岁泰国患者进行探索性横断面危险因素研究。主要目的是确定痤疮患者痤疮瘢痕的重要决定因素，包括社会人口学因素、痤疮临床因素、生活方式因素、饮食习惯因素和治疗因素。采用单变量和多变量逻辑回归来确定重要的风险决定因素。
在225例患者中，痤疮瘢痕患病率为61.33%，发现痤疮瘢痕与以下变量独立相关：中度痤疮（调整后比值比[mOR] 3.51，95%置信区间[CI] 1.31 - 9.40，p = 0.012）或重度至极重度痤疮（mOR 8.98，95% CI 2.71 - 29.73，p < 0.001）、有时挤压和搔抓行为（mOR 2.69，95% CI 2.71 - 29.73，p = 0.033）以及痤疮后红斑（PAE）（mOR 4.46，95% CI 1.96 - 10.14，p < 0.001）。
个体痤疮瘢痕的相关危险因素包括痤疮严重程度、挤压和搔抓行为以及出现PAE。本研究的一项重要发现证实，PAE是可能导致痤疮瘢痕形成的一个显著因素。对有风险的个体进行早期治疗对于减少瘢痕形成至关重要。
