Rehman Sajid Ur, Kong Shuai, Zhang Jing, Xia Haining, Chen Ruiguo, Guo Zeyong, Li Zehua, Ahmed Rida, Rehman Abbas, Kazemian Hossein, Jiang Yanyi, Xu Shuai, Jiang Yuan, Ma Kun, Wang Junfeng
High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China.
Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P.R. China.
Nano Lett. 2024 Dec 11;24(49):15652-15661. doi: 10.1021/acs.nanolett.4c04147. Epub 2024 Nov 27.
For bridging the gap between biological and synthetic materials, the fusion of Metal-Organic Frameworks (MOFs) with biological entities has emerged as a revolutionary strategy in functional materials. In this context, our study introduces a novel structure wherein Bovine Serum Albumin (BSA), a robust and versatile protein, encapsulates zeolitic imidazolate framework-8 (ZIF-8), forming a protein-caged MOF. Highlighting the advantages of this innovative design, the protein-encapsulation enhances the stability and dispersity of ZIF-8, and aids in the synthesis of smaller-sized nanoparticles, crucial for size-impact performance applications. Additionally, the BSA-caged ZIF-8 structure showcases potential in drug delivery applications, especially in the controlled delivery of chemotherapeutic drugs. The study thus elucidates the multifaceted applicability of this novel structure, marking a significant stride in the convergence of biological and synthetic materials.
为了弥合生物材料与合成材料之间的差距，金属有机框架（MOF）与生物实体的融合已成为功能材料领域的一项革命性策略。在此背景下，我们的研究引入了一种新型结构，其中牛血清白蛋白（BSA），一种强大且多功能的蛋白质，包裹着沸石咪唑酯骨架-8（ZIF-8），形成了一种蛋白质笼状MOF。这种创新设计的优势在于，蛋白质封装增强了ZIF-8的稳定性和分散性，并有助于合成尺寸更小的纳米颗粒，这对于尺寸影响性能的应用至关重要。此外，BSA笼状ZIF-8结构在药物递送应用中展现出潜力，尤其是在化疗药物的控释方面。因此，该研究阐明了这种新型结构的多方面适用性，标志着生物材料与合成材料融合方面的重大进展。
