• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一株源自中国的人源甲型流感病毒A(H10N3)的起源、致病性及传播性

Origin, pathogenicity, and transmissibility of a human isolated influenza A(H10N3) virus from China.

作者信息

Zhu Wenfei, Yang Lei, Han Xue, Tan Min, Zou Shumei, Li Xiyan, Huang Weijuan, Zeng Xiaoxu, Wang Dayan

机构信息

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.

Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

出版信息

Emerg Microbes Infect. 2025 Dec;14(1):2432364. doi: 10.1080/22221751.2024.2432364. Epub 2024 Dec 9.

DOI:10.1080/22221751.2024.2432364
PMID:39601280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11632946/
Abstract

Subtype H10 viruses are known to infect humans in Africa, Oceania, and Asia. In 2021, 2022, and recently in April 2024, a novel H10N3 subtype avian influenza virus was found cause human infection with severe pneumonia. Herein, we comprehensively studied the phylogenetic evolution and biological characteristics of the newly emerged influenza A(H10N3) virus. We found that the human isolated H10N3 virus was generated in early 2019 in domestic poultry. The viruses bound to salic acid α2, 3 receptors, indicating their insufficient ability to infect humans. Although a low pathogenic avian influenza virus, the human isolated H10N3 virus exhibited robust pathogenicity in both BALB/c and C57BL/6 mice, with MLD 1000 times higher than a homologous environmental isolate. The human isolated H10N3 also showed respiratory droplet transmissibility in ferrets. Considering the continuous circulation in avian populations and repeated transmission to humans, strengthened surveillance of H10 subtype viruses in poultry should be put into effect.

摘要

已知H10亚型病毒在非洲、大洋洲和亚洲感染人类。2021年、2022年以及最近在2024年4月，发现一种新型H10N3亚型禽流感病毒导致人类感染严重肺炎。在此，我们全面研究了新出现的甲型H10N3流感病毒的系统发育进化和生物学特性。我们发现，人类分离出的H10N3病毒于2019年初在家禽中产生。这些病毒与唾液酸α2,3受体结合，表明它们感染人类的能力不足。尽管人类分离出的H10N3病毒是低致病性禽流感病毒，但在BALB/c和C57BL/6小鼠中均表现出强大的致病性，其半数致死量比同源环境分离株高1000倍。人类分离出的H10N3在雪貂中也表现出呼吸道飞沫传播能力。考虑到该病毒在禽类群体中的持续传播以及反复传播给人类，应加强对家禽中H10亚型病毒的监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/73ed421d3b54/TEMI_A_2432364_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/a347afa1049c/TEMI_A_2432364_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/860310c5f2c2/TEMI_A_2432364_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/f7229597df77/TEMI_A_2432364_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/73ed421d3b54/TEMI_A_2432364_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/a347afa1049c/TEMI_A_2432364_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/860310c5f2c2/TEMI_A_2432364_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/f7229597df77/TEMI_A_2432364_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b9/11632946/73ed421d3b54/TEMI_A_2432364_F0004_OC.jpg

相似文献

1
Origin, pathogenicity, and transmissibility of a human isolated influenza A(H10N3) virus from China.一株源自中国的人源甲型流感病毒A(H10N3)的起源、致病性及传播性
Emerg Microbes Infect. 2025 Dec;14(1):2432364. doi: 10.1080/22221751.2024.2432364. Epub 2024 Dec 9.
2
The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health.新型H10N3禽流感病毒在鸡群中获得了空气传播能力：对公共卫生的威胁日益增加。
mBio. 2025 Feb 5;16(2):e0236324. doi: 10.1128/mbio.02363-24. Epub 2024 Dec 16.
3
Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals.具有适应性突变的 H10N3 流感病毒持续进化，对哺乳动物构成了更大的威胁。
Virol Sin. 2024 Aug;39(4):546-555. doi: 10.1016/j.virs.2024.06.005. Epub 2024 Jun 11.
4
Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets.高致病性禽流感H5N6病毒对人源S型唾液酸受体表现出更高的亲和力，并在雪貂模型中出现接触传播。
J Virol. 2016 Jun 24;90(14):6235-6243. doi: 10.1128/JVI.00127-16. Print 2016 Jul 15.
5
A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes.一种可感染人类的H10N5禽流感病毒：临床特征、病毒重配、受体结合亲和力及可能的传播途径。
J Infect. 2025 Apr;90(4):106456. doi: 10.1016/j.jinf.2025.106456. Epub 2025 Mar 4.
6
Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets.雪鹀源冰岛 H10N7 亚型流感病毒在雪貂中的气溶胶传播。
J Virol. 2019 Jun 14;93(13). doi: 10.1128/JVI.00282-19. Print 2019 Jul 1.
7
A case report of human infection with avian influenza H10N3 with a complex respiratory disease history.人感染 H10N3 禽流感病毒并伴有复杂呼吸系统疾病的病例报告。
BMC Infect Dis. 2024 Sep 4;24(1):918. doi: 10.1186/s12879-024-09830-y.
8
Pathogenesis and Transmission Assessments of Two H7N8 Influenza A Viruses Recently Isolated from Turkey Farms in Indiana Using Mouse and Ferret Models.利用小鼠和雪貂模型对最近从印第安纳州火鸡养殖场分离出的两种H7N8甲型流感病毒进行发病机制和传播评估
J Virol. 2016 Nov 14;90(23):10936-10944. doi: 10.1128/JVI.01646-16. Print 2016 Dec 1.
9
H7N9 influenza viruses are transmissible in ferrets by respiratory droplet.H7N9 流感病毒可通过飞沫在雪貂间传播。
Science. 2013 Jul 26;341(6144):410-4. doi: 10.1126/science.1240532. Epub 2013 Jul 18.
10
Mammalian pathogenicity and transmissibility of low pathogenic avian influenza H7N1 and H7N3 viruses isolated from North America in 2018.2018 年从北美分离的低致病性禽流感 H7N1 和 H7N3 病毒的哺乳动物致病性和传染性。
Emerg Microbes Infect. 2020 Dec;9(1):1037-1045. doi: 10.1080/22221751.2020.1764396.

引用本文的文献

1
A Review of Avian Influenza Virus Exposure Patterns and Risks Among Occupational Populations.职业人群中禽流感病毒暴露模式与风险综述
Vet Sci. 2025 Jul 28;12(8):704. doi: 10.3390/vetsci12080704.
2
Highly pathogenic avian influenza: pandemic preparedness for a scenario of high lethality with no vaccines.高致病性禽流感：在无疫苗情况下应对高致死率疫情的大流行防范措施
Front Public Health. 2025 Jul 16;13:1613869. doi: 10.3389/fpubh.2025.1613869. eCollection 2025.
3
Pathogenicity, transmissibility, and receptor binding of a human-isolated influenza A (H10N5) virus.

本文引用的文献

1
Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals.具有适应性突变的 H10N3 流感病毒持续进化，对哺乳动物构成了更大的威胁。
Virol Sin. 2024 Aug;39(4):546-555. doi: 10.1016/j.virs.2024.06.005. Epub 2024 Jun 11.
2
Biological features of human influenza A(H3N8) viruses in China.中国 H3N8 人流感病毒的生物学特征。
J Med Virol. 2023 Jul;95(7):e28912. doi: 10.1002/jmv.28912.
3
Second Identified Human Infection With the Avian Influenza Virus H10N3: A Case Report.第二例确诊的人感染H10N3禽流感病毒病例报告
一株人源甲型流感病毒（H10N5）的致病性、传播性及受体结合情况
mBio. 2025 Aug 13;16(8):e0073125. doi: 10.1128/mbio.00731-25. Epub 2025 Jul 8.
Ann Intern Med. 2023 Mar;176(3):429-431. doi: 10.7326/L22-0376. Epub 2023 Jan 24.
4
Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021.2014年至2021年在中国分离的H10N3甲型流感病毒的基因分析和生物学特征
J Med Virol. 2023 Feb;95(2):e28476. doi: 10.1002/jmv.28476.
5
Human infection with a reassortment avian influenza A H3N8 virus: an epidemiological investigation study.人感染重配禽流感 A H3N8 病毒：一项流行病学调查研究。
Nat Commun. 2022 Nov 10;13(1):6817. doi: 10.1038/s41467-022-34601-1.
6
Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020.2020 年在中国东部迁徙野生鸟类中检测到的 H10N4 和 H10N8 禽流感病毒的出现、进化和生物学特征。
Microbiol Spectr. 2022 Apr 27;10(2):e0080722. doi: 10.1128/spectrum.00807-22. Epub 2022 Apr 7.
7
Human Infection with an Avian-Origin Influenza A (H10N3) Virus.人感染禽源甲型流感（H10N3）病毒
N Engl J Med. 2022 Mar 17;386(11):1087-1088. doi: 10.1056/NEJMc2112416.
8
Emergence of a novel reassortant avian influenza virus (H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals.新型重配禽流感病毒（H10N3）在中国东部出现，具有高致病性和对哺乳动物的呼吸道飞沫传播能力。
Sci China Life Sci. 2022 May;65(5):1024-1035. doi: 10.1007/s11427-020-1981-5. Epub 2021 Sep 17.
9
Avian influenza H10 subtype viruses continuously pose threat to public health in China.禽流感H10亚型病毒持续对中国的公共卫生构成威胁。
J Infect. 2021 Nov;83(5):607-635. doi: 10.1016/j.jinf.2021.07.039. Epub 2021 Aug 8.
10
The whole genome analysis for the first human infection with H10N3 influenza virus in China.中国首例人感染H10N3流感病毒的全基因组分析。
J Infect. 2021 Jun 27. doi: 10.1016/j.jinf.2021.06.021.