中国首例人感染H10N3流感病毒的全基因组分析。
The whole genome analysis for the first human infection with H10N3 influenza virus in China.
作者信息
Wang Yang, Niu Shaowei, Zhang Bing, Yang Chenghuai, Zhou Zhonghui
机构信息
Department of Infection, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Department of Viral Biologics, China Institute of Veterinary Drug Control, Beijing, China.
出版信息
J Infect. 2021 Jun 27. doi: 10.1016/j.jinf.2021.06.021.
A strain of H10N3 influenza virus, A/Jiangsu/428/2021/H10N3, was isolated from patient in Jiangsu province, eastern China. Phylogenetic analysis illustrated this human H10N3 virus was a low pathogenic avian-origin recombinant virus with HA and NA genes from H10N3 viruses and the other six internal genes from H9N2 viruses. To date, this is the first report of interspecies transmission of an avian H10N3 influenza virus to human.
一株H10N3流感病毒，A/江苏/428/2021/H10N3，从中国东部江苏省的一名患者体内分离出来。系统发育分析表明，这种人源H10N3病毒是一种低致病性禽源重组病毒，其血凝素（HA）和神经氨酸酶（NA）基因来自H10N3病毒，其他六个内部基因来自H9N2病毒。迄今为止，这是禽源H10N3流感病毒跨物种传播给人类的首次报道。
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