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抗癌治疗疗效的祖先差异及其潜在的基因组和分子改变。

Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations.

作者信息

Luo Mei, Yang Jingwen, Schäffer Alejandro A, Chen Chengxuan, Liu Yuan, Chen Yamei, Lin Chunru, Diao Lixia, Zang Yong, Lou Yanyan, Salman Huda, Mills Gordon B, Ruppin Eytan, Han Leng

机构信息

Brown Center for Immunotherapy, School of Medicine, Indiana University, Indianapolis, Indiana.

Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, Indiana.

出版信息

Cancer Discov. 2025 Mar 3;15(3):511-529. doi: 10.1158/2159-8290.CD-24-0827.

DOI:10.1158/2159-8290.CD-24-0827
PMID:39601595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11875934/
Abstract

Our study charts a global landscape of ancestry-associated differences in therapeutic efficacy, highlighting the importance of considering ancestry in anticancer therapies.

摘要

我们的研究描绘了一幅治疗效果中与血统相关差异的全球图景，突出了在抗癌治疗中考虑血统的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/d616d4ffe487/nihms-2040026-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/ea5dea69159d/nihms-2040026-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/eb0aa80e3478/nihms-2040026-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/39a1a3cc63d8/nihms-2040026-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/5d2bc45c39c7/nihms-2040026-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/8494340859fa/nihms-2040026-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/d616d4ffe487/nihms-2040026-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/ea5dea69159d/nihms-2040026-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/eb0aa80e3478/nihms-2040026-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/39a1a3cc63d8/nihms-2040026-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/5d2bc45c39c7/nihms-2040026-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/8494340859fa/nihms-2040026-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a45/11875934/d616d4ffe487/nihms-2040026-f0006.jpg

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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.通过对 187 个新风险变体的多祖裔全基因组发现，描绘前列腺癌风险。
Nat Genet. 2023 Dec;55(12):2065-2074. doi: 10.1038/s41588-023-01534-4. Epub 2023 Nov 9.
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Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers.
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Cancer Cell. 2023 Nov 13;41(11):1963-1971.e3. doi: 10.1016/j.ccell.2023.10.003. Epub 2023 Oct 26.
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