Área Clínica de Imagen Médica, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Department of Radiology, Seoul National University Hospital, Seoul, South Korea.
Radiologia (Engl Ed). 2024 Oct;66 Suppl 2:S75-S88. doi: 10.1016/j.rxeng.2024.05.002. Epub 2024 Oct 21.
The use of hepatobiliary-specific contrast agents in liver MRI is a crucial diagnostic tool for evaluating liver disease, enabling the detection and characterisation of focal lesions and vascular alterations, as well as the assessment and grading of chronic hepatopathy. Paramagnetic hepatobiliary-specific contrast agents are gadolinium-based, partially taken up by hepatocytes, and excreted via both renal and biliary pathways. There are two linear ionic molecules that are currently commercially available: gadobenic acid (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA). Their main clinical indications include distinguishing and characterising focal liver lesions on healthy liver tissue, diagnosing and staging hepatocellular carcinoma in patients with chronic hepatopathy, and increasing reliability in the detection of hepatic metastases in oncology patients, especially prior to surgery. They are also useful in the evaluation of the biliary tract and in assessing complications of hepatic surgery such as bile leaks.
肝胆特异性对比剂在肝脏 MRI 中的应用是评估肝脏疾病的重要诊断工具，可用于检测和描述局灶性病变和血管改变，以及评估和分级慢性肝病。顺磁性肝胆特异性对比剂基于钆，部分被肝细胞摄取，并通过肾脏和胆道途径排泄。目前有两种线性离子分子在临床上可用：钆贝葡胺（Gd-BOPTA）和钆塞酸二钠（Gd-EOB-DTPA）。它们的主要临床适应证包括在正常肝组织上区分和描述局灶性肝脏病变，诊断和分期慢性肝病患者的肝细胞癌，以及提高肿瘤患者肝转移检测的可靠性，尤其是在手术前。它们在胆管评估和评估肝脏手术后的并发症（如胆汁漏）方面也很有用。
