Habibi Mohammad Amin, Ahmadvand Muhammad Hussain, Delbari Pouria, Sabet Saba, Zare Amir Hessam, Mirjani Mohammad Sina, Boskabadi Amir Reza, Kolur Zahra Aslani, Bozorgi Maryam
Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Neuroradiol J. 2024 Nov 27:19714009241303083. doi: 10.1177/19714009241303083.
The pRESET stent retriever is a self-expanding nitinol stent designed for mechanical thrombectomy in cases of large vessel occlusion during acute ischemic stroke. This systematic review and meta-analysis synthesize the available evidence on the safety and efficacy of the pRESET device.
This is a systematic review and meta-analysis study conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The electronic databases of PubMed, Embase, WoS, and Scopus were systematically reviewed from inception to 8 July 2024.
A total of eight studies involving 1163 patients were included. The pooled mortality rate was 18% with a 95% CI of [12%, 25%]. The rates of any hemorrhagic complication, parenchymal hemorrhage, and subarachnoid hemorrhage were 22% with a 95% CI of [12%, 36%], 7% with a 95% CI of [4%, 13%], and 10% with a 95% CI of [5%, 17%], respectively. The rate of favorable functional outcome (modified Rankin Scale 0-2) at 90 days was 43% with a 95% CI of [34%, 52%]. Successful recanalization rates were 60% with a 95% CI of [52%, 67%] after the first pass and 90% with a 95% CI of [83%, 95%] after the final pass. Rescue devices were used in 13% with a 95% CI of [7%, 24%] of cases.
The pRESET stent retriever demonstrates high recanalization rates and reasonable safety outcomes in patients undergoing mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion. Further randomized trials directly comparing pRESET to other stent retrievers are warranted.
pRESET 支架取栓器是一种自膨胀镍钛诺支架，设计用于急性缺血性卒中期间大血管闭塞病例的机械取栓。本系统评价和荟萃分析综合了关于 pRESET 装置安全性和有效性的现有证据。
这是一项基于系统评价和荟萃分析的首选报告项目（PRISMA）进行的系统评价和荟萃分析研究。对 PubMed、Embase、WoS 和 Scopus 的电子数据库从创建到 2024 年 7 月 8 日进行了系统检索。
共纳入 8 项研究，涉及 1163 例患者。汇总死亡率为 18%，95%置信区间为[12%，25%]。任何出血并发症、实质内出血和蛛网膜下腔出血的发生率分别为 22%，95%置信区间为[12%，36%]；7%，95%置信区间为[4%，13%]；10%，95%置信区间为[5%，17%]。90 天时良好功能结局（改良 Rankin 量表 0 - 2 级）的发生率为 43%，95%置信区间为[34%，52%]。首次通过后成功再通率为 60%，95%置信区间为[52%，67%]；最终通过后为 90%，95%置信区间为[83%，95%]。13%的病例使用了补救装置，95%置信区间为[7%，24%]。
pRESET 支架取栓器在因大血管闭塞接受急性缺血性卒中机械取栓的患者中显示出高再通率和合理的安全性结果。有必要进行进一步的随机试验，将 pRESET 与其他支架取栓器直接进行比较。
