Coulam C B, Adamson S C, Annegers J F
Obstet Gynecol. 1986 Apr;67(4):604-6.
To assess the occurrence of premature ovarian failure, the age-specific incidence rates of natural menopause were determined for a cohort of 1858 women born between 1928 and 1932. These women were identified as Rochester, Minnesota residents in 1950 and were followed for date and type of menopause. A total of nine experienced natural menopause before age 40 years, which represents a 1% risk of natural menopause to age 40. The annual incidence rates of natural menopause per 100,000 person-years were ten for ages 15 to 29 and 76 for ages 30 to 39. In the age group 40 to 44, the incidence of natural menopause increased greatly to 881 per 100,000 person-years at risk.
为评估卵巢早衰的发生率，对1858名出生于1928年至1932年间的女性队列确定了特定年龄的自然绝经发病率。这些女性在1950年被确定为明尼苏达州罗切斯特市的居民，并对其绝经日期和类型进行了随访。共有9名女性在40岁之前经历了自然绝经，这代表40岁之前自然绝经的风险为1%。每10万人年的自然绝经年发病率在15至29岁年龄段为10例，在30至39岁年龄段为76例。在40至44岁年龄组，处于风险中的每10万人年自然绝经发病率大幅上升至881例。
