Yao Chunhui, Zhang Wanlu, Bao Peng, Ma Jie, Zhuo Wei, Chen Minjia, Shi Zhitian, Zhou Jingwen, Ye Yuxiao, Ming Liang, Yan Ting, Penty Richard, Cheng Qixiang
Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, UK.
GlitterinTech Limited, Xuzhou, China.
Nat Commun. 2024 Nov 27;15(1):10305. doi: 10.1038/s41467-024-54708-x.
Miniaturized spectrometers hold great promise for in situ, in vitro, and even in vivo sensing applications. However, their size reduction imposes vital performance constraints in meeting the rigorous demands of spectroscopy, including fine resolution, high accuracy, and ultra-wide observation window. The prevailing view in the community holds that miniaturized spectrometers are most suitable for coarse identification of signature peaks. Here, we present an integrated reconstructive spectrometer that enables near-infrared (NIR) spectroscopic metrology, and demonstrate a fully packaged sensor with auxiliary electronics. Such a sensor operates over a 520 nm bandwidth together with a resolution below 8 pm, yielding a record-breaking bandwidth-to-resolution ratio of over 65,000. The classification of different types of solid substances and the concentration measurement of aqueous and organic solutions are performed, all achieving approximately 100% accuracy. Notably, the detection limit of our sensor matches that of commercial benchtop counterparts, which is as low as 0.1% (i.e. 100 mg/dL) for identifying the concentration of glucose solution.
小型光谱仪在原位、体外甚至体内传感应用方面具有巨大潜力。然而，其尺寸的减小对满足光谱学的严格要求施加了重要的性能限制，这些要求包括精细分辨率、高精度和超宽观测窗口。该领域的普遍观点认为，小型光谱仪最适合对特征峰进行粗略识别。在此，我们展示了一种能够实现近红外（NIR）光谱计量的集成式重构光谱仪，并展示了一种带有辅助电子设备的全封装传感器。这种传感器在520纳米带宽上运行，分辨率低于8皮米，产生了超过65000的破纪录带宽分辨率比。对不同类型的固体物质进行了分类，并对水溶液和有机溶液进行了浓度测量，所有这些都实现了约100%的准确率。值得注意的是，我们传感器的检测限与商用台式同类产品相当，对于识别葡萄糖溶液浓度低至0.1%（即100毫克/分升）。
