Park Jeongwoo, Shin Eun Jin, Kim Tae Hyun, Yang Ji Hye, Ki Sung Hwan, Kang Keon Wook, Kim Kyu Min
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, 61452, Republic of Korea.
Arch Pharm Res. 2024 Dec;47(12):893-913. doi: 10.1007/s12272-024-01519-9. Epub 2024 Nov 28.
Cellular metabolism-related epigenetic modulation plays a pivotal role in the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) serves as a crucial link between cellular metabolism and epigenetics by catalyzing nicotinamide methylation using the universal methyl donor S-adenosyl-L-methionine. This direct connection bridges the methylation-mediated one-carbon metabolism with nicotinamide adenine dinucleotide levels. Numerous studies have revealed tissue-specific differences in NNMT expression and activity, indicating that its varied physiological and pathological roles depend on its distribution. In this review, we provide an overview of the NNMT involvement in various pathological conditions, including cancer, liver disease, obesity, diabetes, brain disease, pulmonary disease, cardiovascular disease, and kidney disease. By synthesizing this information, our article aims to enhance our understanding of the cellular mechanisms underlying NNMT biology related to diverse diseases and lay the molecular groundwork for developing therapeutic strategies for pharmacological interventions.
细胞代谢相关的表观遗传调控在维持细胞内稳态中起关键作用。烟酰胺N-甲基转移酶（NNMT）通过使用通用甲基供体S-腺苷-L-甲硫氨酸催化烟酰胺甲基化，在细胞代谢和表观遗传学之间起着关键联系。这种直接联系将甲基化介导的一碳代谢与烟酰胺腺嘌呤二核苷酸水平联系起来。大量研究揭示了NNMT表达和活性的组织特异性差异，表明其不同的生理和病理作用取决于其分布。在这篇综述中，我们概述了NNMT在各种病理状况中的作用，包括癌症、肝脏疾病、肥胖症、糖尿病、脑部疾病、肺部疾病、心血管疾病和肾脏疾病。通过综合这些信息，我们的文章旨在加深我们对与多种疾病相关的NNMT生物学潜在细胞机制的理解，并为开发药物干预治疗策略奠定分子基础。
