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腹部结核性肿块病变引起的梗阻性黄疸。

Obstructive jaundice caused by an abdominal tuberculous mass lesion.

作者信息

Liu Wilson Jing Peng, Wu Michael Yulong, Zaborowski Matthew, Ng Eugene

机构信息

Royal North Shore Hospital, Reserve Road, St Leonards, NSW, 2065, Australia.

Northern Clinical School, University of Sydney, Sydney, NSW, Australia.

出版信息

Clin J Gastroenterol. 2025 Feb;18(1):202-207. doi: 10.1007/s12328-024-02070-2. Epub 2024 Nov 28.

Abstract

Tuberculosis is a global epidemic infection that typically presents with symptoms affecting the respiratory system. Abdominal tuberculosis is an uncommon manifestation, occurring in only 5% of tuberculosis cases globally and can present with a broad range of vague symptoms that mimic other biliary and pancreatic pathologies. We report a case of a 36-year-old woman presenting with jaundice and biliary obstruction secondary to abdominal tuberculosis. Computed tomography and magnetic resonance cholangiopancreatography revealed a loculated retroperitoneal mass abutting the pancreatic head and duodenum with associated common bile duct dilatation. Endoscopic ultrasound demonstrated an ulcerated mass in the duodenum which was biopsied. Necrotising granulomas were identified on histology and the biopsied tissue was positive on tuberculosis polymerase chain reaction testing. Thus, extrapulmonary abdominal tuberculosis was diagnosed. The patient was commenced on a 6-month course of rifampicin, isoniazid, pyrazinamide and ethambutol treatment and demonstrated complete response to medical therapy. Abdominal tuberculosis can be difficult to diagnose but should remain an important differential to be considered for patients with previous travel or residence in endemic areas presenting with gastrointestinal symptoms. Prompt diagnosis and treatment can prevent unnecessary procedures, complications and death in patients with biliary obstruction caused by abdominal tuberculosis.

摘要

结核病是一种全球性的流行性感染疾病,通常表现为影响呼吸系统的症状。腹部结核是一种不常见的表现形式,在全球仅5%的结核病例中出现,可表现出一系列类似其他胆道和胰腺疾病的模糊症状。我们报告一例36岁女性患者,因腹部结核继发黄疸和胆道梗阻。计算机断层扫描和磁共振胰胆管造影显示,一个位于腹膜后的局限性肿块紧邻胰头和十二指肠,并伴有胆总管扩张。内镜超声显示十二指肠有一个溃疡肿块,遂进行活检。组织学检查发现坏死性肉芽肿,结核聚合酶链反应检测显示活检组织呈阳性。因此,诊断为肺外腹部结核。该患者开始接受为期6个月的利福平、异烟肼、吡嗪酰胺和乙胺丁醇治疗,对药物治疗显示出完全反应。腹部结核可能难以诊断,但对于有疫区旅行或居住史且出现胃肠道症状的患者,应始终将其作为一个重要的鉴别诊断考虑因素。及时诊断和治疗可预防腹部结核所致胆道梗阻患者的不必要检查、并发症和死亡。

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