母体运动模式对婴儿脐带血蛋白质组的影响。
Effects of maternal exercise modes on infant cord blood proteome.
作者信息
Jevtovic Filip, Wisseman Breanna, Jahan Fahmida, Claiborne Alex, Collier David N, DeVente James E, Mouro Steven, Zeczycki Tonya, Goodyear Laurie J, May Linda E
机构信息
Department of Kinesiology, East Carolina University, Greenville, NC, USA.
Human Performance Laboratory, East Carolina University, Greenville, NC, USA.
出版信息
bioRxiv. 2024 Nov 14:2024.11.11.623083. doi: 10.1101/2024.11.11.623083.
The aim of this study was to show the effects of different maternal exercise modes on infant cord blood proteome. We used infant cord blood from two randomized controlled trials where women with a wide range of BMI and free of pregnancy complications participated in controlled and supervised aerobic, resistance, or combination (aerobic+resistance) exercise from <16 weeks of gestation until delivery. Results of this study showed that infant cord blood proteome is altered in a maternal exercise mode specific manner. Additionally, results showed 61 downregulated proteins common to all exercise modes, which correspond to gas transport, cellular stress response, reactive oxygen species metabolism, and other biological processes. Collectively, these data demonstrate the differential effect of maternal exercise modes on infant cord blood proteome.
本研究的目的是展示不同的母体运动模式对婴儿脐带血蛋白质组的影响。我们使用了来自两项随机对照试验的婴儿脐带血，在这两项试验中，BMI范围广泛且无妊娠并发症的女性从妊娠<16周开始直至分娩参与了有控制的、有监督的有氧运动、抗阻运动或联合运动（有氧运动+抗阻运动）。本研究结果表明，婴儿脐带血蛋白质组以母体运动模式特异性的方式发生改变。此外，结果显示所有运动模式共有61种下调蛋白，这些蛋白与气体运输、细胞应激反应、活性氧代谢及其他生物学过程相关。总体而言，这些数据证明了母体运动模式对婴儿脐带血蛋白质组的不同影响。
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