Barrett M J, Hurwitz E S, Schonberger L B, Rogers M F
Pediatrics. 1986 Apr;77(4):598-602.
The average annual incidence of Reye syndrome reported through national surveillance was lower during 1981 to 1984 than during the previous five surveillance years. This is accounted for by a decrease in cases among children younger than 10 years of age; the number of cases in 10- to 19-year-old persons remained relatively stable during this period. The overall decline in incidence and the differing age-specific incidence trends are apparent for both varicella-associated cases and for nonvaricella-associated cases. During 1985, the incidence has been much lower than during any previous year since surveillance was initiated; this most recent decrease includes children 10 to 19 years of age. Independently conducted surveys suggest that the prevalence of salicylate use for viral illnesses has decreased among children in recent years, particularly among children younger than 10 years of age. The changing epidemiology of Reye syndrome may reflect, in part, the declining use of salicylates among children and teenagers in the United States.
通过国家监测报告的瑞氏综合征年均发病率在1981年至1984年期间低于此前五个监测年份。这是由于10岁以下儿童病例数减少所致；在此期间，10至19岁人群中的病例数保持相对稳定。水痘相关病例和非水痘相关病例的发病率总体下降以及不同年龄组发病率的不同趋势均很明显。1985年，发病率比监测开始以来的任何一年都低得多；最近的这次下降包括10至19岁的儿童。独立开展的调查表明，近年来儿童中用于治疗病毒性疾病的水杨酸盐使用率有所下降，尤其是10岁以下儿童。瑞氏综合征流行病学的变化可能部分反映了美国儿童和青少年中水杨酸盐使用量的下降。
