- Universidade Federal da Paraíba, Curso de Medicina - João Pessoa - PB - Brasil.
- Universidade Federal da Paraíba, Departamento de Cirurgia - João Pessoa - PB - Brasil.
Rev Col Bras Cir. 2024 Nov 25;51:e20243757. doi: 10.1590/0100-6991e-20243757-en. eCollection 2024.
The aim of this study was to conduct a scoping review on the efficacy of phosphodiesterase-5 inhibitors (PDE-5Is) in rehabilitating erectile function in patients undergoing cavernous nerve sparing radical prostatectomy (NSRP).
The databases used were MEDLINE, EMBASE, CENTRAL, LILACS and Web of Science. Systematic reviews with meta-analyses on the subject were included until March 5, 2024, with no language restrictions. Publications that did not address any of the aforementioned relationships were excluded. The data was organized into tables for descriptive analysis. The methodological quality of the included studies was assessed using the ROBIS tool.
Eight studies were selected and all concluded that the use of PDE-5Is is effective in penile rehabilitation. Only one of the reviews found that use for more than six months was superior to short-term use, and another concluded that daily use was superior to on-demand use. In addition, the articles identified more adverse effects in the experimental group compared to the control group, but without compromising therapeutic adherence. Six of the studies were classified as low risk of bias, while the other two had uncertain risk.
PDE-5Is are effective in restoring erectile function in patients undergoing NSRP, especially when used regularly and over the long term, and follow-up is not hampered by adverse effects. However, due to the scarcity of data, new studies should be carried out to determine the best form of use of these drugs.
本研究旨在对磷酸二酯酶-5 抑制剂（PDE-5Is）在保留海绵体神经的根治性前列腺切除术（NSRP）后恢复勃起功能方面的疗效进行范围性综述。
使用的数据库包括 MEDLINE、EMBASE、CENTRAL、LILACS 和 Web of Science。纳入了截至 2024 年 3 月 5 日关于该主题的系统评价和荟萃分析，无语言限制。排除了未涉及上述任何关系的出版物。数据被组织成表格进行描述性分析。使用 ROBIS 工具评估纳入研究的方法学质量。
共选择了 8 项研究，所有研究均得出 PDE-5Is 对阴茎康复有效。只有一项综述发现使用超过 6 个月优于短期使用，另一项综述则得出每日使用优于按需使用。此外，与对照组相比，文章确定了实验组更多的不良影响，但没有影响治疗的依从性。6 项研究被归类为低偏倚风险，而另外 2 项研究具有不确定的风险。
PDE-5Is 可有效恢复 NSRP 患者的勃起功能，尤其是当长期规律使用且随访不受不良反应影响时。然而，由于数据匮乏，应开展新的研究以确定这些药物的最佳使用方式。
