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鱼类：上颌窦提升的一种新异种移植物来源。

Fish: a new xenograft source for maxillary sinus lifting.

机构信息

Erciyes University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery and DentBioChem Biotechnology Co., Erciyes Teknopark, Kayseri, Türkiye.

Erciyes University, Faculty of Science, Department of Hydrobiology, Kayseri, Türkiye.

出版信息

J Appl Oral Sci. 2024 Nov 22;32:e20240245. doi: 10.1590/1678-7757-2024-0245. eCollection 2024.

DOI:10.1590/1678-7757-2024-0245
PMID:39607250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643101/
Abstract

OBJECTIVE

Although autogenous grafting is accepted as the gold standard in intraoral grafting, xenogenous grafts are frequently used in sinus lift surgeries due to their osteoinductive and osteoconductive properties. This study aimed to investigate the efficacy of fish spine-derived xenogenic grafts in sinus augmentation surgery.

MATERIAL AND METHODS

In this study, a fish spine-derived xenogenic graft was produced for comparison with autogenous graft and bovine derived xenogenic grafts. Twenty-one New Zealand rabbits were used. Autogenous grafts (AG- Group 1), as well as bovine-derived (bHAP - Group 2) and fish spine-derived (fHAP - Group 3) xenogenic grafts were placed in the right and left sinuses of rabbits. The animals were sacrificed at the 4th and 8th weeks. New bone formation (NBF) was evaluated through histological examination, while bone volume (BV), new bone surface/bone volume (BS-BV), new bone surface/tissue volume (BS-TV), and trabecular separation (Tb-Sp) were assessed via Micro-CT. Statistical significance was considered at p<0.05.

RESULTS

Histological examination revealed a significant difference in NBF between AG-bHAP (p<0.001), as well as between fHAP-bHAP (p<0.001) in the fourth-week group. No significant difference was found in the eighth-week group (p=0.130). In the eighth-week group, a statistically significant difference was found between fHAP and bHAP in terms of BV. (p=0.007).

CONCLUSION

Although both graft materials used in this study showed positive effects on bone regeneration, fHAP and AG presented similar effects on bone regeneration and were superior to bHAP.

摘要

目的

尽管自体移植物被认为是口腔内移植的金标准，但由于其成骨和骨诱导特性，异种移植物在鼻窦提升手术中经常被使用。本研究旨在探讨鱼脊柱来源的异种移植物在鼻窦增大手术中的效果。

材料和方法

在这项研究中，制备了一种鱼脊柱来源的异种移植物，与自体移植物和牛来源的异种移植物进行比较。使用 21 只新西兰兔。将自体移植物（AG-组 1）以及牛来源的（bHAP-组 2）和鱼脊柱来源的（fHAP-组 3）异种移植物分别置于兔子的右侧和左侧鼻窦中。在第 4 周和第 8 周处死动物。通过组织学检查评估新骨形成（NBF），通过 Micro-CT 评估骨体积（BV）、新骨表面/骨体积（BS-BV）、新骨表面/组织体积（BS-TV）和小梁分离（Tb-Sp）。p<0.05 时认为具有统计学意义。

结果

组织学检查显示，在第 4 周组中，AG-bHAP（p<0.001）和 fHAP-bHAP（p<0.001）之间的 NBF 存在显著差异。第 8 周组无显著差异（p=0.130）。在第 8 周组中，fHAP 和 bHAP 之间的 BV 存在统计学显著差异（p=0.007）。

结论

尽管本研究中使用的两种移植物材料都对骨再生有积极的影响，但 fHAP 和 AG 在骨再生方面的效果相似，优于 bHAP。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/62e788f8ba30/1678-7765-jaos-32-e20240245-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/47c08168fb35/1678-7765-jaos-32-e20240245-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/fd5c4dd3c9cd/1678-7765-jaos-32-e20240245-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/ab92ef9327bc/1678-7765-jaos-32-e20240245-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/64e21e94ce32/1678-7765-jaos-32-e20240245-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/62e788f8ba30/1678-7765-jaos-32-e20240245-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/47c08168fb35/1678-7765-jaos-32-e20240245-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/fd5c4dd3c9cd/1678-7765-jaos-32-e20240245-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/ab92ef9327bc/1678-7765-jaos-32-e20240245-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/64e21e94ce32/1678-7765-jaos-32-e20240245-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90ca/11643101/62e788f8ba30/1678-7765-jaos-32-e20240245-gf05.jpg

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本文引用的文献

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Xenograft materials in maxillary sinus floor elevation surgery: a systematic review with network meta-analyses.上颌窦底提升术中的异种移植材料：一项网络荟萃分析的系统评价
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Decellularized Adipose Tissue Hydrogel Promotes Bone Regeneration in Critical-Sized Mouse Femoral Defect Model.去细胞脂肪组织水凝胶促进临界尺寸小鼠股骨缺损模型中的骨再生。
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