Department of Otorhinolaryngology-Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Yonsei Med J. 2024 Dec;65(12):741-751. doi: 10.3349/ymj.2024.0142.
Sensorineural hearing loss (SNHL) is prevalent among older adults in the United States. Recent studies suggest the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a potential marker for metabolic and cardiovascular conditions. Our research investigates the association between the TG/HDL-C ratio and SNHL using a comprehensive national dataset.
This cross-sectional study utilized the National Health and Nutrition Examination Survey (NHANES) data cycle 1999-2000, 2001-2002, 2003-2004, 2011-2012, and 2015-2016. Participants aged 50-69 years with complete audiometry and TG/HDL-C data were included. The outcome was the presence of SNHL, defined as an average hearing threshold >25 dB in the better ear. We employed multivariate logistic regression adjusted for demographics, smoking, noise exposure, and comorbidities to explore the association.
A total of 1148 participants constituted the analytic sample, and 31.4% had SNHL. Compared to no SNHL, those with SNHL exhibited higher TG/HDL-C ratios (3.5 vs. 2.7). Elevated TG/HDL-C tertiles correlated with increased SNHL odds [tertile 2: adjusted odds ratio (aOR)=1.50, 95% confidence interval (CI): 0.97-2.32, =0.069; tertile 3: aOR=1.64, 95% CI: 1.03-2.63, =0.039]. The link was stronger in participants without diabetes or obesity, with significant predictive values for SNHL presence (area under the ROC curve=0.716 and 0.753, respectively).
A higher TG/HDL-C ratio was significantly associated with SNHL in US adults aged 50-69 years, especially in those free from diabetes or obesity. These findings support considering TG/HDL-C as a useful marker for SNHL risk, highlighting the importance of combined metabolic and auditory health assessments.
在美国，老年人中普遍存在感音神经性听力损失（SNHL）。最近的研究表明，甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值可作为代谢和心血管状况的潜在标志物。我们的研究使用综合国家数据集，调查了 TG/HDL-C 比值与 SNHL 之间的关联。
本横断面研究使用了国家健康和营养检查调查（NHANES）数据周期 1999-2000、2001-2002、2003-2004、2011-2012 和 2015-2016。纳入年龄在 50-69 岁之间、具有完整听力图和 TG/HDL-C 数据的参与者。结果是存在 SNHL，定义为较好耳的平均听力阈值>25dB。我们采用多元逻辑回归调整了人口统计学、吸烟、噪声暴露和合并症，以探讨关联。
共有 1148 名参与者构成了分析样本，其中 31.4%患有 SNHL。与无 SNHL 相比，SNHL 患者的 TG/HDL-C 比值更高（3.5 比 2.7）。升高的 TG/HDL-C 三分位数与 SNHL 几率增加相关[三分位数 2：调整后的优势比（aOR）=1.50，95%置信区间（CI）：0.97-2.32，=0.069；三分位数 3：aOR=1.64，95%CI：1.03-2.63，=0.039]。在无糖尿病或肥胖的参与者中，这种关联更强，对 SNHL 存在具有显著的预测价值（ROC 曲线下面积分别为 0.716 和 0.753）。
在美国 50-69 岁成年人中，较高的 TG/HDL-C 比值与 SNHL 显著相关，尤其是在没有糖尿病或肥胖的人群中。这些发现支持将 TG/HDL-C 视为 SNHL 风险的有用标志物，强调了代谢和听觉健康综合评估的重要性。
