Tang Xuemiao, He Qiuhua, Liu XiaoYe, Fu Qiang
Department of Anesthesiology, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
Department of Anesthesiology, The First People's Hospital of Zigong, Zigong, Sichuan, China.
Medicine (Baltimore). 2025 May 2;104(18):e42337. doi: 10.1097/MD.0000000000042337.
Lipid profile disturbances are frequently observed in depressive patients. Triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) can be reflective of the level of blood lipids. However, it remains unclear whether higher TG/HDL-C increases the risk of depression. This study aimed to investigate the association between TG/HDL-C and depression. In this cross-sectional study, 20,406 participants were analyzed from the National Health and Nutrition Examination Survey between 2005 and 2020. A weighted multivariable logistic regression model, restricted cubic spline regression model and threshold effect analysis were used to explore the association of TG/HDL-C with depression risk. A total of 20,406 participants who had complete data on TG/HDL-C and depression measurement were included in this study (median age 47 years, 50.51% female). Participants with depression had higher TG/HDL-C than those without depression (0.97 [0.54-1.64] vs 0.82 [0.50-1.38], P < .001). TG/HDL-C was associated with an increased risk of depression after adjusting for all covariates (in model 3: odds ratio (OR) = 1.31, 95% confidence interval (CI): 1.04-1.64, P = .02). Moreover, a nonlinear J-shaped relationship was observed between TG/HDL-C ratio and the risk of depression, with an inflection point of 0.402 by threshold effect analysis. These findings indicate that TG/HDL-C has a J-shaped association with the risk of depression (P for non-linearity = .008).
在抑郁症患者中经常观察到血脂异常。甘油三酯与高密度脂蛋白胆固醇之比（TG/HDL-C）可反映血脂水平。然而，较高的TG/HDL-C是否会增加抑郁症风险仍不清楚。本研究旨在探讨TG/HDL-C与抑郁症之间的关联。在这项横断面研究中，对2005年至2020年期间美国国家健康与营养检查调查中的20406名参与者进行了分析。采用加权多变量逻辑回归模型、受限立方样条回归模型和阈值效应分析来探讨TG/HDL-C与抑郁症风险的关联。本研究共纳入20406名有TG/HDL-C和抑郁症测量完整数据的参与者（中位年龄47岁，女性占50.51%）。抑郁症患者的TG/HDL-C高于无抑郁症患者（0.97[0.54 - 1.64]对0.82[0.50 - 1.38]，P < 0.001）。在对所有协变量进行调整后，TG/HDL-C与抑郁症风险增加相关（模型3中：比值比（OR）= 1.31，95%置信区间（CI）：1.04 - 1.64，P = 0.02）。此外，通过阈值效应分析观察到TG/HDL-C比值与抑郁症风险之间存在非线性J形关系，拐点为0.402。这些发现表明，TG/HDL-C与抑郁症风险呈J形关联（非线性P = 0.008）。
