Wang Yixuan, Liu Hui, Nie Xinlin, Lu Na, Yan Sheng, Wang Xin, Zhao Yuxiang
Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an, China.
Yan'an University, Yan'an, China.
Front Endocrinol (Lausanne). 2024 Feb 23;15:1339731. doi: 10.3389/fendo.2024.1339731. eCollection 2024.
The association between the sensorineural hearing loss (SNHL) and triglyceride-glucose (TyG) index remains inadequately understood. This investigation seeks to elucidate the connection between the TyG index and SNHL.
In this cross-sectional study, we utilized datasets sourced from the National Health and Nutrition Examination Survey (NHANES). A comprehensive analysis was conducted on 1,851 participants aged 20 to 69, utilizing complete audiometry data from the NHANES database spanning from 2007 to 2018. All enrolled participants had accessible hearing data, and the average thresholds were measured and calculated as both low-frequency pure-tone average and high-frequency pure-tone average. Sensorineural hearing loss (SNHL) was defined as an average pure tone of 20 dB or higher in at least one better ear. Our analysis involved the application of multivariate linear regression models to examine the linear relationship between the TyG index and SNHL. To delineate any non-linear associations, we utilized fitted smoothing curves and conducted threshold effect analysis. Furthermore, we conducted a two-sample Mendelian randomization (MR) study, leveraging genetic data from genome-wide association studies (GWAS) on circulating lipids, blood glucose, and SNHL. The primary analytical method for the MR study was the application of the inverse-variance-weighted (IVW) approach.
In our multivariate linear regression analysis, a substantial positive correlation emerged between the TyG index and SNHL [2.10 (1.80-2.44), p < 0.0001]. Furthermore, using a two-segment linear regression model, we found an L-shaped relationship between TyG index, fasting blood glucose and SNHL with an inflection point of 9.07 and 94 mg/dL, respectively. Specifically, TyG index [3.60, (1.42-9.14)] and blood glucose [1.01, (1.00-1.01)] concentration higher than the threshold values was positively associated with SNHL risk. Genetically determined triglyceride levels demonstrated a causal impact on SNHL (OR = 1.092, p = 8.006 × 10). In addition, blood glucose was found to have a protective effect on SNHL (OR = 0.886, p = 1.012 × 10).
An L-shaped association was identified among the TyG index, fasting blood glucose, and SNHL in the American population. TyG index of more than 9.07 and blood glucose of more than 94 mg/dL were significantly and positively associated with SNHL risk, respectively.
感音神经性听力损失（SNHL）与甘油三酯-葡萄糖（TyG）指数之间的关联仍未得到充分理解。本研究旨在阐明TyG指数与SNHL之间的联系。
在这项横断面研究中，我们使用了来自美国国家健康与营养检查调查（NHANES）的数据集。对1851名年龄在20至69岁之间的参与者进行了全面分析，利用了NHANES数据库中2007年至2018年的完整听力测定数据。所有纳入的参与者都有可获取的听力数据，并测量和计算了平均阈值，包括低频纯音平均值和高频纯音平均值。感音神经性听力损失（SNHL）被定义为至少一只较好耳朵的平均纯音为20分贝或更高。我们的分析涉及应用多元线性回归模型来检验TyG指数与SNHL之间的线性关系。为了描述任何非线性关联，我们使用了拟合平滑曲线并进行了阈值效应分析。此外，我们进行了一项两样本孟德尔随机化（MR）研究，利用了来自全基因组关联研究（GWAS）的关于循环脂质、血糖和SNHL的遗传数据。MR研究的主要分析方法是应用逆方差加权（IVW）方法。
在我们的多元线性回归分析中，TyG指数与SNHL之间出现了显著的正相关[2.10（1.80 - 2.44），p < 0.0001]。此外，使用两段线性回归模型，我们发现TyG指数、空腹血糖与SNHL之间呈L形关系，拐点分别为9.07和94毫克/分升。具体而言，TyG指数[3.60，（1.42 - 9.14）]和血糖[浓度高于阈值时为1.01，（1.00 - 1.01）]与SNHL风险呈正相关。遗传确定的甘油三酯水平对SNHL有因果影响（OR = 1.092，p = 8.006 × 10）。此外，发现血糖对SNHL有保护作用（OR = 0.886，p = 1.012 × 10）。
在美国人群中，TyG指数、空腹血糖与SNHL之间存在L形关联。TyG指数大于9.07和血糖大于94毫克/分升分别与SNHL风险显著正相关。
