Department of Public Health, Institute of Social and Cultural Studies, Lahore, Pakistan.
WVU Medicine, 1 Medical Center Drive, Morgantown, WV, 26505, USA.
Nutr J. 2024 Nov 28;23(1):147. doi: 10.1186/s12937-024-01046-9.
Despite the popularity and potential protective effects of intermittent fasting (IF) against metabolic disorders, more human trials must be conducted to highlight its effects on human health. Therefore, the present trial aimed to investigate the effect of IF on the body composition, health markers, and memory status of obese and overweight adults.
A parallel randomised controlled trial was conducted in Lahore, Pakistan, with 30 participants recruited from each of the three arms (regular diet, customised diet, and IF group) with a follow-up period of 12 weeks.
There was no significant difference in the mean percentage change in BMI at the end of the study period (p = 0.55). The IF group exhibited a negative median change (-4.41%) in systolic blood pressure compared with the other two groups (p = 0.014), with no difference among the groups in diastolic blood pressure or blood sugar levels (p > 0.05). The percentage change in waist circumference was more significant in the IF group than in the control group, with a significant improvement in the median percentage change in total cholesterol, LDL, triglyceride, and HDL levels (p < 0.05) as well as in the memory score (p < 0.05).
This study revealed that IF helps improve participants' lipid parameters, systolic blood pressure, and memory status.
The present study is registered at the registry of Clinicaltrials.gov with identity number NCT05521945 and registration date 30/08/22.
尽管间歇性禁食（IF）在治疗代谢紊乱方面广受欢迎且可能具有保护作用，但仍需要更多的人体试验来强调其对人类健康的影响。因此，本试验旨在研究 IF 对肥胖和超重成年人的身体成分、健康指标和记忆状态的影响。
本研究在巴基斯坦拉合尔进行了一项平行随机对照试验，从常规饮食组、定制饮食组和 IF 组中各招募 30 名参与者，随访期为 12 周。
在研究结束时，BMI 的平均百分比变化没有显著差异（p=0.55）。与其他两组相比，IF 组的收缩压中位数呈负向变化（-4.41%）（p=0.014），但两组间的舒张压或血糖水平无差异（p>0.05）。IF 组的腰围百分比变化较对照组更为显著，总胆固醇、LDL、甘油三酯和 HDL 水平的中位数百分比变化以及记忆评分均有显著改善（p<0.05）。
本研究表明 IF 有助于改善参与者的血脂参数、收缩压和记忆状态。
本研究在 Clinicaltrials.gov 注册，注册号为 NCT05521945，注册日期为 2022 年 8 月 30 日。
