Park Wooyoung, Cha Seungwoo, Hahn Ji-Sook
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
ACS Synth Biol. 2024 Dec 20;13(12):3788-3798. doi: 10.1021/acssynbio.4c00519. Epub 2024 Nov 29.
The use of one-carbon (C1) feedstocks, including carbon dioxide (CO), carbon monoxide (CO), formate (HCOH), methanol (CHOH), and methane (CH), presents a significant opportunity for sustainable bioproduction and environmental conservation. This Perspective explores the development of biological methods for converting C1 feedstocks into valuable products, emphasizing major progress from engineering native C1 assimilation pathways to the creation of synthetic autotrophs and methylotrophs that utilize these carbon sources. Additionally, we discuss hybrid approaches that merge biological and electrochemical systems, particularly for the conversion of CO. This Perspective underscores the importance of C1 bioconversion in promoting sustainable biotechnological strategies for a low-carbon future.
使用一碳（C1）原料，包括二氧化碳（CO₂）、一氧化碳（CO）、甲酸盐（HCOOH）、甲醇（CH₃OH）和甲烷（CH₄），为可持续生物生产和环境保护提供了重大机遇。本观点探讨了将C1原料转化为有价值产品的生物学方法的发展，重点介绍了从改造天然C1同化途径到创建利用这些碳源的合成自养生物和甲基营养生物的主要进展。此外，我们还讨论了融合生物和电化学系统的混合方法，特别是用于CO₂转化的方法。本观点强调了C1生物转化在促进低碳未来可持续生物技术战略中的重要性。
