评估局部用药制剂治疗糖尿病性神经病变的疗效：一项叙述性综述
Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review.
作者信息
Elbeddini Ali, Tanvir Azasma, Yilmaz Orhan, Rahman Yusra, Mongon Renata
机构信息
Family Medicine Department, University of Ottawa, School of Medicine, 600 Peter Morand Crescent Suite 201, Ottawa, ON K1G 5Z3 Canada.
College of Medicine, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK S7N 5E5 Canada.
出版信息
J Diabetes Metab Disord. 2024 Jul 3;23(2):1613-1620. doi: 10.1007/s40200-024-01459-7. eCollection 2024 Dec.
BACKGROUND
We conducted a review of topical medications available for alleviation of diabetic neuropathic pain (DNP) and compared their efficacy with oral medications for pain relief. We also explored the feasibility of compounding topical medications.
METHODS
Searches on PubMed, Medline Ovid, and Embase databases were conducted and findings were presented as a narrative review.
RESULTS AND DISCUSSION
8% Capsaicin patches and 5% Lidocaine patches had the most evidence. The literature also showed evidence for topical clonidine, gabapentin, and amitriptyline.
CONCLUSION
Topical formulations are a potential substitute to oral medications in patients suffering from DNP. Potential options include 8% Capsaicin patch, 5% Lidocaine patch, Clonidine gel, Topical gabapentin, and an amitriptyline and ketamine combination. A promising area of research that requires further study is the effect of a combination of topicals in alleviated DNP.
背景
我们对可用于缓解糖尿病性神经病变疼痛（DNP）的外用药物进行了综述，并将它们缓解疼痛的疗效与口服药物进行了比较。我们还探讨了配制外用药物的可行性。
方法
在PubMed、Medline Ovid和Embase数据库中进行检索，并以叙述性综述的形式呈现研究结果。
结果与讨论
8%辣椒素贴剂和5%利多卡因贴剂有最多的证据支持。文献中也显示了外用可乐定、加巴喷丁和阿米替林的证据。
结论
外用制剂是DNP患者口服药物的一种潜在替代方案。潜在的选择包括8%辣椒素贴剂、5%利多卡因贴剂、可乐定凝胶、外用加巴喷丁以及阿米替林和氯胺酮的组合。一个需要进一步研究的有前景的研究领域是外用药物联合使用对缓解DNP的效果。
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