Abrams Rory M C, Pedowitz Elizabeth J, Simpson David M
Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, New York, NY 10019.
Department of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, 1468 Madison Avenue, New York, 10029, NY.
Expert Rev Neurother. 2021 Mar;21(3):259-266. doi: 10.1080/14737175.2021.1874920. Epub 2021 Feb 4.
Diabetes is an increasingly prevalent disorder affecting nearly 1-in-5 adults, of which half will experience diabetic peripheral neuropathy (DPN) and a quarter will suffer from diabetic peripheral nerve pain (DPNP), severely impacting quality of life. The currently approved treatment options are typically centrally acting agents whose use is limited by systemic effects and drug interactions. The capsaicin 8% dermal patch was recently approved by the U.S. FDA for the treatment of DPNP.
The authors review the available literature regarding the use of high-concentration capsaicin 8% patch for the treatment of diabetic peripheral neuropathy and neuropathic pain and discuss implementing its use in clinical practice.
The high-concentration capsaicin 8% patch is an effective and well-tolerated treatment option for treating DPNP. Capsaicin 8% patch may be used alone or in combination with other oral therapies and can provide rapid and sustained neuropathic pain relief following a single application and is safe and effective when used long term.
糖尿病是一种日益普遍的疾病，影响着近五分之一的成年人，其中一半会出现糖尿病周围神经病变（DPN），四分之一会遭受糖尿病周围神经疼痛（DPNP），严重影响生活质量。目前获批的治疗选择通常是中枢作用药物，其使用受到全身效应和药物相互作用的限制。8%辣椒素皮肤贴剂最近被美国食品药品监督管理局（FDA）批准用于治疗DPNP。
作者回顾了关于使用8%高浓度辣椒素贴剂治疗糖尿病周围神经病变和神经病理性疼痛的现有文献，并讨论在临床实践中应用该贴剂。
8%高浓度辣椒素贴剂是治疗DPNP的一种有效且耐受性良好的治疗选择。8%辣椒素贴剂可单独使用或与其他口服疗法联合使用，单次应用后可迅速且持续缓解神经病理性疼痛，长期使用安全有效。
