College of Integrated Traditional Chinese & Western Medicine, Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China.
Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Front Immunol. 2024 Nov 13;15:1480596. doi: 10.3389/fimmu.2024.1480596. eCollection 2024.
The study provides a thorough examination of literature from 2013 to 2023, delving into the intricate relationship between mitochondrial function and colorectal cancer (CRC). It offers a concise overview of the current landscape and emerging trends in this rapidly evolving research area. The findings indicate a consistent rise in annual publications, reflecting growing interest and significant potential in the field. China emerges as the leading contributor, followed by the United States and India. However, despite China's dominance in output, its average citation rate is lower than that of the US, which leads in citations per publication, highlighting a noticeable disparity. In the realm of research institutions, Shanghai Jiao Tong University and China Medical University are identified as major contributors, yet the potential for inter-institutional collaboration remains largely untapped, suggesting avenues for future synergy. Internationally, China-US collaborations are particularly robust, fostering cross-border knowledge exchange. Hyun Jin Won and Li Wei are recognized as prolific authors, while Ahmedin Jemal is an influential co-cited scholar, noted for his seminal contributions. Keyword analysis reveals research focus areas, such as the complex CRC tumor microenvironment, molecular mechanisms of oxidative stress, and key multidrug resistance pathways. It also highlights the promising potential of mitochondria-targeted therapies and nanomolecular technologies in clinical practice, signaling their growing significance in addressing complex health challenges. The study underscores the imperative to validate complex mitochondrial mechanisms and signaling pathways in CRC, with a particular emphasis on translating these insights into drug targets for clinical trials. Advancing this research is expected to refine and enhance CRC treatment strategies. Additionally, it highlights the urgency of validating mitochondrial complexities in CRC, advocating for collaborative efforts to link these mechanisms with tailored therapeutic interventions for clinical testing. This integrated approach promises significant advancements in developing effective, targeted CRC treatments, ultimately improving patient outcomes.
本研究对 2013 年至 2023 年的文献进行了全面考察，深入探讨了线粒体功能与结直肠癌（CRC）之间的复杂关系。它提供了对这一快速发展研究领域当前格局和新兴趋势的简明概述。研究结果表明，每年发表的论文数量持续增加，反映出该领域日益增长的兴趣和巨大潜力。中国是主要贡献者，其次是美国和印度。然而，尽管中国在产出方面占据主导地位，但它的平均引用率低于美国，美国在每篇论文的引用率方面处于领先地位，这凸显了明显的差距。在研究机构方面，上海交通大学和中国医科大学是主要贡献者，但机构间合作的潜力仍在很大程度上未被开发，这表明未来存在协同作用的潜力。在国际上，中美合作尤为强劲，促进了跨境知识交流。Hyun Jin Won 和 Li Wei 被认为是多产作者，而 Ahmedin Jemal 则是一位有影响力的共同引用学者，以其开创性贡献而闻名。关键词分析揭示了研究重点领域，如复杂的 CRC 肿瘤微环境、氧化应激的分子机制以及关键的多药耐药途径。它还强调了线粒体靶向治疗和纳米分子技术在临床实践中的广阔应用前景，表明它们在应对复杂健康挑战方面的重要性日益增加。该研究强调了在 CRC 中验证复杂的线粒体机制和信号通路的必要性，特别强调将这些见解转化为临床试验的药物靶点。推进这项研究有望完善和增强 CRC 的治疗策略。此外，它还强调了在 CRC 中验证线粒体复杂性的紧迫性，提倡开展合作努力，将这些机制与针对特定患者的治疗干预措施联系起来，进行临床测试。这种综合方法有望在开发有效的、靶向性的 CRC 治疗方法方面取得重大进展，最终改善患者的治疗效果。
