Fu Li, Song Tianyuan, Li Qi, Zou Guizheng, Zhang Fuwei, Li Zongchao, Guan Haotian, Guo Yingshu
School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250100, China.
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Analyst. 2024 Dec 16;150(1):34-45. doi: 10.1039/d4an01314j.
The oxidative-reduction electrochemiluminescence (ECL) potential of a luminophore is one of the most significant parameters during light generation processes when considering the growing demand for anti-interference analysis techniques, electrode compatibility and the reduction of damage to biological molecules due to excessive excitation potential. Nanoparticle luminophores, including quantum dots (QDs) and metal nanoclusters (NCs), possess tremendous potential for forming various ECL sensors due to their adjustable surface states. However, few reviews focused on nanoparticle luminophore-based ECL systems for low-triggering-potential (LTP) oxidative-reduction ECL to avoid the possible interference and oxidative damage of biological molecules. This review summarizes the recent advances in the LTP oxidative-reduction ECL potential strategy with nanoparticle luminophores as ECL emitters, including matching efficient coreactants and nanoparticle luminophores, doping nanoparticle luminophores, constructing donor-acceptor systems, choosing suitable working electrodes, combining multiplex nanoparticle luminophores, and employing surface-engineering strategies. In the context of the different LTP ECL systems, potential-lowering strategies and bio-related applications are discussed in detail. Additionally, the future trends and challenges of low ECL-triggering-potential strategies are discussed.
在考虑对抗干扰分析技术、电极兼容性以及减少由于过高激发电位对生物分子造成损伤的需求不断增长的情况下，发光体的氧化还原电化学发光（ECL）电位是光生成过程中最重要的参数之一。包括量子点（QDs）和金属纳米团簇（NCs）在内的纳米颗粒发光体，由于其可调节的表面状态，在形成各种ECL传感器方面具有巨大潜力。然而，很少有综述关注基于纳米颗粒发光体的ECL系统用于低触发电位（LTP）氧化还原ECL，以避免生物分子可能受到的干扰和氧化损伤。本综述总结了以纳米颗粒发光体作为ECL发射体的LTP氧化还原ECL电位策略的最新进展，包括匹配高效共反应剂和纳米颗粒发光体、掺杂纳米颗粒发光体、构建供体 - 受体系统、选择合适的工作电极、组合多重纳米颗粒发光体以及采用表面工程策略。在不同的LTP ECL系统背景下，详细讨论了降低电位策略和生物相关应用。此外，还讨论了低ECL触发电位策略的未来趋势和挑战。
