Wang Jialu, Xiang Yi, Chen Zhiqi, Lu Wenyi, Zhou Yiquan, Mao Xiaomeng, Tang Molian, Zou Jing, Song Anqi, Tang Qingya, Xu Renying
Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Clinical Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Endocrine. 2025 Apr;88(1):91-98. doi: 10.1007/s12020-024-04118-2. Epub 2024 Nov 29.
We aim to evaluate the effects of partial meal replacement (MR) with different timing of MR on body weight in Chinese adults.
A multicenter open-labeled, randomized, parallel study was performed. Participants were randomly assigned to receive partial MR at breakfast and lunch or breakfast and dinner for 16 weeks. The primary outcome was the absolute change in body weight between baseline and the end of the intervention. The BMI of participants is between 24.0 kg/m and 35.0 kg/m, without a history of diabetes, hypertension, or gout, and whose baseline blood pressure, fasting blood glucose, serum level of glycated hemoglobin A1c, uric acid, and liver enzymes within the pre-determined range, were recruited.
A total number of 153 individuals were included in the analysis (106 females and 47 males; mean age 32.6 ± 6.7 years, mean BMI 28.5 ± 2.8 kg/m at baseline). Partial MR for 16 weeks resulted in significant body weight loss (-5.1 kg, 95% CI: -5.8, -4.5 kg), decrease of waist (-4.8 cm; 95% CI: -5.5 cm, -4.1 cm) and hip circumference (-4.3 cm; 95% CI: -4.9 cm, -3.8 cm), and loss of body fat (-4.1 kg; 95% CI: -4.7 kg, -3.6 kg). About half of the participants (51.6%) achieved the goal of losing 5% of baseline body weight or more. Timings of MR (breakfast and lunch vs. breakfast and dinner) generated similar results.
Partial MR resulted in significant improvements in anthropometric data, body fat, and most metabolic variables while different MR timing generated similar results.
The study was registered at https://www.chictr.org.cn/showproj.html?proj=47475 (ChiCTR2100042637).
我们旨在评估在中国成年人中，不同时间进行部分代餐（MR）对体重的影响。
进行了一项多中心、开放标签、随机、平行研究。参与者被随机分配在早餐和午餐或早餐和晚餐时接受部分代餐，为期16周。主要结局是干预基线至结束时体重的绝对变化。招募了BMI在24.0kg/m至35.0kg/m之间、无糖尿病、高血压或痛风病史且基线血压、空腹血糖、糖化血红蛋白A1c血清水平、尿酸和肝酶在预定范围内的参与者。
共有153人纳入分析（女性106人，男性47人；平均年龄32.6±6.7岁，基线时平均BMI 28.5±2.8kg/m）。16周的部分代餐导致体重显著减轻（-5.1kg，95%CI：-5.8，-4.5kg），腰围减小（-4.8cm；95%CI：-5.5cm，-4.1cm）和臀围减小（-4.3cm；95%CI：-4.9cm，-3.8cm），以及体脂减少（-4.1kg；95%CI：-4.7kg，-3.6kg）。约一半的参与者（51.6%）实现了减轻基线体重5%或更多的目标。代餐时间（早餐和午餐与早餐和晚餐）产生了相似的结果。
部分代餐在人体测量数据、体脂和大多数代谢变量方面有显著改善，而不同的代餐时间产生了相似的结果。
该研究在https://www.chictr.org.cn/showproj.html?proj=47475（ChiCTR2100042637）注册。
