Li Chenxi, Shang Wenwen, Huang Yuzhe, Ge Jing, Ye Jinqiu, Qu Xin, Guo Quanyi, Wang Ce, Hu Ping, Liu Yong
Beijing Key Laboratory of Advanced Functional Polymer Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Institute of Orthopedics, The Fourth Medical Center, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
Int J Biol Macromol. 2025 Jan;285:138054. doi: 10.1016/j.ijbiomac.2024.138054. Epub 2024 Nov 27.
Cartilage repair remains a significant challenge in tissue engineering. The Sodium alginate/Chitosan hydrogel scaffold, fabricated from natural polymers, has the potential to promote tissue regeneration. However, its poor mechanical performance limits its application. Research has shown that integrating nanomaterials into three-dimensional network materials can significantly enhance mechanical properties, which is particularly important for osteochondral replacement scaffolds. In this study, biodegradable polylactic acid-glycolic acid copolymer/polycaprolactone/gelatin (PLGA/PCL/GEL) nanofibers were prepared via electrospinning and integrated as a reinforcing phase. This enhancement significantly improved the mechanical performance of the sodium alginate/chitosan hydrogel, achieving a maximum compressive modulus of 665 kPa and compressive stress of 342 kPa. Moreover, the inherent biocompatibility of the composite scaffold remained high. This work demonstrates the potential of nanofiber/hydrogel scaffolds, contributing to the development of safe and multifunctional materials for clinical application.
软骨修复仍是组织工程领域的一项重大挑战。由天然聚合物制成的海藻酸钠/壳聚糖水凝胶支架具有促进组织再生的潜力。然而，其较差的力学性能限制了它的应用。研究表明，将纳米材料整合到三维网络材料中可以显著提高力学性能，这对于骨软骨置换支架尤为重要。在本研究中，通过静电纺丝制备了可生物降解的聚乳酸-乙醇酸共聚物/聚己内酯/明胶（PLGA/PCL/GEL）纳米纤维，并将其作为增强相进行整合。这种增强显著提高了海藻酸钠/壳聚糖水凝胶的力学性能，实现了665 kPa的最大压缩模量和342 kPa的压缩应力。此外，复合支架的固有生物相容性仍然很高。这项工作证明了纳米纤维/水凝胶支架的潜力，有助于开发用于临床应用的安全且多功能的材料。
