Ide Amber D, Grainger Stephanie
Department of Cell Biology, Van Andel Institute, Grand Rapids, MI, 49503, USA.
Department of Cell Biology, Van Andel Institute, Grand Rapids, MI, 49503, USA.
Differentiation. 2025 Mar-Apr;142:100820. doi: 10.1016/j.diff.2024.100820. Epub 2024 Nov 22.
WNT9 paralogues, WNT9A and WNT9B, are secreted ligands driving both the canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signaling pathways. These pathways play roles in cell fate determination, embryonic patterning, bone development, and organogenesis, among other biological processes. Studies of Wnt9a and Wnt9b mutant animals demonstrate that they have specific and overlapping roles in these processes. Wnt9a is critical in directing stem and progenitor cell fate during hematopoietic stem cell development, proper bone formation, and chondrogenesis, while Wnt9b is important for kidney and heart development. Both proteins are essential in craniofacial development and convergent extension movements. Dysregulated expression of human WNT9A and WNT9B have been implicated in different cancers and disease, suggesting these proteins or their downstream pathways may represent potential therapeutic targets.
WNT9旁系同源物WNT9A和WNT9B是分泌型配体，可驱动经典（β-连环蛋白依赖性）和非经典（β-连环蛋白非依赖性）Wnt信号通路。这些通路在细胞命运决定、胚胎模式形成、骨骼发育和器官发生等多种生物学过程中发挥作用。对Wnt9a和Wnt9b突变动物的研究表明，它们在这些过程中具有特定的重叠作用。Wnt9a在造血干细胞发育、正常骨形成和软骨形成过程中指导干细胞和祖细胞命运方面至关重要，而Wnt9b对肾脏和心脏发育很重要。这两种蛋白质在颅面发育和汇聚延伸运动中都是必不可少的。人类WNT9A和WNT9B的表达失调与不同的癌症和疾病有关，这表明这些蛋白质或其下游通路可能代表潜在的治疗靶点。
