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基于抗菌肽的局部给药系统在种植体周围炎早期治疗中的有效性

Effectiveness of a Local Drug Delivery System Based on Antimicrobial Peptides in Early Treatment of Peri-implantitis.

作者信息

Liu Xiling, Liu Lan, Zeng Zheng

机构信息

Department of Stomatology, The Ninth Hospital of Wuhan, Wuhan, Hubei Province, China.

Department Ophthalmology, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China.

出版信息

Int Dent J. 2025 Apr;75(2):1400-1408. doi: 10.1016/j.identj.2024.11.001. Epub 2024 Nov 30.

DOI:10.1016/j.identj.2024.11.001
PMID:39616083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11976603/
Abstract

OBJECTIVE

To analyse the effects of titanium implants coated with various antimicrobial peptide (AMP) layers on bacterial growth and early biofilm formation around the implants.

METHODS

A novel AMP mixture was constructed using Type I collagen, sulfonated succinimide 4- (N-Maleimidylphenyl) butyrate, and AMPs. Titanium discs treated with chitosan and hyaluronic acid solutions were reacted with the AMP mixture to obtain AMP-coated titanium discs. The drug release properties and inhibitory effects on the growth and early biofilm formation of Porphyromonasgingivalis (P. gingivalis) ATCC BAA-308 or Staphylococcus aureus (S. aureus) ATCC 25923 were analysed.

RESULTS

The antimicrobial activity of the 9-layer AMP-coated titanium discs against P. gingivalis ATCC BAA-308 and S.aureus ATCC 25923 was greatly higher relative to the 3-layer and 6-layer AMP-coated titanium discs (P < .05). The overall optical density and average optical density of titanium discs coated with 6 and 9 layers of AMPs were markedly inferior to those of uncoated titanium discs and discs coated with 3 layers of AMPs (P < .05). The drug release amounts from titanium discs coated with different layers of AMPs increased over time.

CONCLUSIONS

The prepared AMP-coated titanium discs effectively inhibit the growth of P. gingivalis and S. aureus, as well as early biofilm formation. The drug-laced discs demonstrate good durability and predictability in drug release, which may be beneficial for long-term therapeutic adoption.

摘要

目的

分析涂覆有不同抗菌肽（AMP）层的钛植入物对植入物周围细菌生长和早期生物膜形成的影响。

方法

使用I型胶原蛋白、磺化琥珀酰亚胺4-（N-马来酰亚胺基苯基）丁酸酯和抗菌肽构建一种新型的AMP混合物。将用壳聚糖和透明质酸溶液处理过的钛盘与AMP混合物反应，以获得涂覆有AMP的钛盘。分析其药物释放特性以及对牙龈卟啉单胞菌（P. gingivalis）ATCC BAA - 308或金黄色葡萄球菌（S. aureus）ATCC 25923生长和早期生物膜形成的抑制作用。

结果

相对于3层和6层涂覆有AMP的钛盘，9层涂覆有AMP的钛盘对牙龈卟啉单胞菌ATCC BAA - 308和金黄色葡萄球菌ATCC 25923的抗菌活性显著更高（P <.05）。涂覆有6层和9层AMP的钛盘的总体光密度和平均光密度明显低于未涂覆的钛盘和涂覆有3层AMP的钛盘（P <.05）。不同层数AMP涂覆的钛盘的药物释放量随时间增加。

结论

制备的涂覆有AMP的钛盘能有效抑制牙龈卟啉单胞菌和金黄色葡萄球菌的生长以及早期生物膜形成。含药盘在药物释放方面表现出良好的耐久性和可预测性，这可能有利于长期治疗应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/cab181d0787c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/25e3279fa98f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/fe21df3db035/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/16fe83c5341e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/d23d706ecdea/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/0e0d2e867189/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/b13612243665/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/4f3aa7f183e6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/cab181d0787c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/25e3279fa98f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/fe21df3db035/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/16fe83c5341e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/d23d706ecdea/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/0e0d2e867189/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/b13612243665/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/4f3aa7f183e6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f136/11976603/cab181d0787c/gr8.jpg

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