微循环参数作为高度近视眼后巩膜葡萄肿进展预测的危险因素：一项病例对照研究

Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.

作者信息

Li Haoru, Gao Nan, Li Ruixin, Luodian Luobu, Sui Jinyuan, Bai Yang, Wu Di, He Qing, Wang Yuxin, Li Zhiqing, Wei Ruihua

机构信息

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

出版信息

Eye Vis (Lond). 2024 Dec 1;11(1):45. doi: 10.1186/s40662-024-00413-1.

DOI:10.1186/s40662-024-00413-1

PMID:39616369

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11608478/

Abstract

BACKGROUND

To assess the rate of macular blood flow decreasing in adults with and without posterior staphyloma (PS) using optical coherence tomography angiography (OCTA) and to identify risk factors associated with PS progression.

METHODS

This longitudinal case-control study enrolled 122 eyes of 122 patients-64 patients with PS (PS group) and 58 patients without PS (NPS group). Participants underwent OCTA and clinical examinations at least twice, and those followed for at least one year were included in the analysis. Logistic regression analysis and machine learning were applied to explore the risk factors for PS and its progression.

RESULTS

Patients in the PS group exhibited faster growth rates of spherical equivalent refraction (SER), axial length (AL), curvature index (CI), and posterior scleral height (PSH) as well as higher loss rates of choriocapillaris perfusion area (CCPA), choroid perfusion area (CPA) and choroidal vascularity index (CVI) compared to the NPS group (all P < 0.05). The baseline SER (B = - 1.291, OR = 0.275, P = 0.008), baseline subfoveal scleral thickness (B = - 1.621, OR = 0.198, P = 0.046), baseline PSH (B = 2.959, OR = 19.282, P = 0.001) and foveal CVI changes per year (B = - 2.776, OR = 0.062, P < 0.001) were the risk factors for PS. Baseline AL (B = 0.561, OR = 1.752, P = 0.033), parafoveal choroidal thickness changes per year (B = - 0.094, OR = 0.910, P = 0.032), foveal retinal vascular density changes per year (B = 0.104, OR = 1.110, P = 0.013) and foveal CCPA changes per year (B = - 0.214, OR = 0.807, P = 0.038) were the risk factors for the PS progression.

CONCLUSIONS

During the progression of myopia in adults, changes in the morphology of the eye's posterior pole are not limited to axial lengthening alone; there also will be a phase of compensatory lateral expansion. Baseline AL and changes in the microcirculation can be utilized to predict the progression of PS.

摘要

背景

使用光学相干断层扫描血管造影（OCTA）评估有和没有后巩膜葡萄肿（PS）的成年人黄斑血流减少率，并确定与PS进展相关的危险因素。

方法

这项纵向病例对照研究纳入了122例患者的122只眼，其中64例患有PS（PS组），58例没有PS（NPS组）。参与者至少接受两次OCTA和临床检查，将随访至少一年的患者纳入分析。应用逻辑回归分析和机器学习来探索PS及其进展的危险因素。

结果

与NPS组相比，PS组患者的球镜等效屈光度（SER）、眼轴长度（AL）、曲率指数（CI）和后巩膜高度（PSH）的增长率更快，脉络膜毛细血管灌注面积（CCPA）、脉络膜灌注面积（CPA）和脉络膜血管指数（CVI）的损失率更高（所有P<0.05）。基线SER（B=-1.291，OR=0.275，P=0.008）、基线黄斑下巩膜厚度（B=-1.621，OR=0.198，P=0.046）、基线PSH（B=2.959，OR=19.282，P=0.001）和每年黄斑CVI变化（B=-2.776，OR=0.062，P<0.001）是PS的危险因素。基线AL（B=0.561，OR=1.752，P=0.033）、每年黄斑旁脉络膜厚度变化（B=-0.094，OR=0.910，P=0.032）、每年黄斑视网膜血管密度变化（B=0.104，OR=1.110，P=0.013）和每年黄斑CCPA变化（B=-0.214，OR=0.807，P=0.038）是PS进展的危险因素。