Wen Baoquan, Weng Xiqing, Zhu Shujun, Wu Xiujuan, Lin Xiaofeng, Chen Hong, He Yuqin
Encephalopathy Department, Shunde Hospital of GuangZhou University of Chinese Medicine, Foshan, China.
Encephalopathy Department, Shunde Hospital of GuangZhou University of Chinese Medicine, Foshan, China.
Int J Biol Macromol. 2025 Jan;285:138194. doi: 10.1016/j.ijbiomac.2024.138194. Epub 2024 Nov 29.
The brain tumors have been characterized with aggressive and heterogeneous nature. The treatment of brain tumors has been challenging due to their sensitive location and also, presence of blood-brain barrier (BBB) that reduces the entrance of bioactive compounds to the brain tissue. Therefore, the new treatment strategies should be focused on improving the efficacy of conventional therapeutics, crossing over biological barriers and introducing new kinds of methods for brain tumor elimination. In the recent years, the application of carbohydrate polymers in the treatment of human cancers has been increased as they possess biocompatibility, biodegradability and selective targeting of tumor cells. Moreover, carbohydrate polymer-based nanoparticles demonstrate desirable drug loading and encapsulation, making them suitable for the delivery of bioactive compounds. Accordingly, the carbohydrate polymers and their nanoparticles have been developed to improve the drug and gene delivery to brain tumors. Moreover, these nanoparticles can increase sensitivity of chemotherapy and immunotherapy. In addition to providing combination therapy, the carbohydrate polymer-based nanoparticles can elevate the phototherapy-mediated tumor ablation. These nanocarriers have demonstrated desirable particle size, zeta potential and encapsulation efficiency that are beneficial for brain tumor therapy. Moreover, these nanoparticles have high biocompatibility that can be subsequently utilized in clinical studies.
脑肿瘤具有侵袭性和异质性。由于其位置敏感以及血脑屏障（BBB）的存在，血脑屏障会减少生物活性化合物进入脑组织，因此脑肿瘤的治疗一直具有挑战性。所以，新的治疗策略应专注于提高传统疗法的疗效、跨越生物屏障以及引入新型脑肿瘤消除方法。近年来，碳水化合物聚合物在人类癌症治疗中的应用有所增加，因为它们具有生物相容性、可生物降解性以及对肿瘤细胞的选择性靶向作用。此外，基于碳水化合物聚合物的纳米颗粒表现出理想的药物负载和包封能力，使其适合用于生物活性化合物的递送。因此，已经开发出碳水化合物聚合物及其纳米颗粒以改善向脑肿瘤的药物和基因递送。此外，这些纳米颗粒可以提高化疗和免疫疗法的敏感性。除了提供联合治疗外，基于碳水化合物聚合物的纳米颗粒还可以提高光疗介导的肿瘤消融效果。这些纳米载体表现出理想的粒径、zeta电位和包封效率，这对脑肿瘤治疗有益。此外，这些纳米颗粒具有高生物相容性，随后可用于临床研究。
