Tveden-Nyborg Pernille, Yang Baoxue, Simonsen Ulf, Lykkesfeldt Jens
Section of Preclinical Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Pharmacology, Peking University, China.
Basic Clin Pharmacol Toxicol. 2024 Dec;135(6):782-785. doi: 10.1111/bcpt.14109. Epub 2024 Dec 1.
Natural products constitute a vast source of bioactive compounds with the potential of providing valuable insight for future medicines. However, from a pharmacological perspective, natural product studies are also often accompanied by serious limitations due to, for example, the complex nature of biological extracts, the challenge of reproducibly characterizing the extract and providing an exhaustive list of constituents and, consequently, the difficulties in linking the observed pharmacological effects to specific chemical entities. The present paper discusses the major challenges of studies with natural products and provides a guideline to be followed by authors submitting research findings involving data from natural products, and their derivatives, to Basic & Clinical Pharmacology & Toxicology.
天然产物是生物活性化合物的巨大来源，有可能为未来药物提供有价值的见解。然而，从药理学角度来看，天然产物研究也常常伴随着严重的局限性，例如生物提取物的复杂性质、可重复地表征提取物并提供详尽成分列表的挑战，以及因此将观察到的药理作用与特定化学实体联系起来的困难。本文讨论了天然产物研究的主要挑战，并为向《基础与临床药理学与毒理学》提交涉及天然产物及其衍生物数据的研究结果的作者提供了一份指南。
